ID   HAP1 EPHB4 (-)
AC   CVCL_SM23
SY   HZGHC001278c011; HZGHC2050; EPHB4 knockout cell line 13bp deletion
DR   cancercelllines; CVCL_SM23
DR   Horizon_Discovery; HZGHC001278c011
DR   Wikidata; Q54873793
RX   PubMed=31659326;
CC   Group: Haploid karyotype cell line.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; 3395; EPHB4.
CC   Sequence variation: Gene fusion; HGNC; 76; ABL1 + HGNC; 1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Ser215Gly (c.643A>G); ClinVar=VCV000265337; Zygosity=Hemizygous (from parent cell line).
CC   Discontinued: Horizon_Discovery; HZGHC001278c011; true.
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C3174; Chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_Y019 ! HAP1
SX   Male
AG   40Y
CA   Cancer cell line
DT   Created: 14-05-18; Last updated: 30-01-24; Version: 12
//
RX   PubMed=31659326; DOI=10.1038/s41592-019-0614-5;
RA   Smits A.H., Ziebell F., Joberty G., Zinn N., Mueller W.F.,
RA   Clauder-Munster S., Eberhard D., Falth Savitski M., Grandi P.,
RA   Jakob P., Michon A.-M., Sun H., Tessmer K., Burckstummer T.,
RA   Bantscheff M., Steinmetz L.M., Drewes G., Huber W.;
RT   "Biological plasticity rescues target activity in CRISPR knock outs.";
RL   Nat. Methods 16:1087-1093(2019).
//