ID   Mel-RMu
AC   CVCL_S994
SY   Mel-RMU; Mel RMu; MelRMu
DR   BTO; BTO:0005719
DR   cancercelllines; CVCL_S994
DR   Cosmic; 889011
DR   Cosmic; 1941942
DR   Wikidata; Q54905130
RX   PubMed=10364001;
RX   PubMed=15048078;
RX   PubMed=22383533;
RX   PubMed=23455323;
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=15048078; PubMed=22383533; PubMed=23455323).
CC   Sequence variation: Mutation; HGNC; 9612; PTK2B; Simple; p.Arg429Cys (c.1285C>T); dbSNP=rs201274282; Zygosity=Heterozygous (PubMed=22383533).
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 05-10-23; Version: 16
//
RX   PubMed=10364001;
RA   Zhang X.-D., Franco A., Myers K., Gray C., Nguyen T., Hersey P.;
RT   "Relation of TNF-related apoptosis-inducing ligand (TRAIL) receptor
RT   and FLICE-inhibitory protein expression to TRAIL-induced apoptosis of
RT   melanoma.";
RL   Cancer Res. 59:2747-2753(1999).
//
RX   PubMed=15048078; DOI=10.1038/sj.onc.1207563;
RA   Pavey S., Johansson P., Packer L., Taylor J., Stark M.S., Pollock P.M.,
RA   Walker G.J., Boyle G.M., Harper U., Cozzi S.-J., Hansen K., Yudt L.,
RA   Schmidt C., Hersey P., Ellem K.A.O., O'Rourke M.G.E., Parsons P.G.,
RA   Meltzer P.S., Ringner M., Hayward N.K.;
RT   "Microarray expression profiling in melanoma reveals a BRAF mutation
RT   signature.";
RL   Oncogene 23:4060-4067(2004).
//
RX   PubMed=22383533; DOI=10.1158/1535-7163.MCT-11-0676;
RA   Dutton-Regester K., Irwin D., Hunt P., Aoude L.G., Tembe V.,
RA   Pupo G.M., Lanagan C., Carter C.D., O'Connor L., O'Rourke M.,
RA   Scolyer R.A., Mann G.J., Schmidt C.W., Herington A., Hayward N.K.;
RT   "A high-throughput panel for identifying clinically relevant mutation
RT   profiles in melanoma.";
RL   Mol. Cancer Ther. 11:888-897(2012).
//
RX   PubMed=23455323; DOI=10.1038/onc.2013.45;
RA   Becker T.M., Boyd S.C., Mijatov B., Gowrishankar K., Snoyman S.,
RA   Pupo G.M., Scolyer R.A., Mann G.J., Kefford R.F., Zhang X.D.,
RA   Rizos H.;
RT   "Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3
RT   transcription factor.";
RL   Oncogene 33:1158-1166(2014).
//