ID   cen3tel
AC   CVCL_S896
SY   Cen3tel; Cen3 tel
DR   GEO; GSE15742
DR   Wikidata; Q54809292
RX   PubMed=12927806;
RX   PubMed=16357149;
RX   PubMed=21209796;
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: In situ; Skin, dermis; UBERON=UBERON_0002067.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_B5SM ! cen3
SX   Female
AG   102Y
CA   Telomerase immortalized cell line
DT   Created: 03-02-14; Last updated: 10-04-25; Version: 10
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RX   PubMed=12927806; DOI=10.1016/S0006-291X(03)01484-0;
RA   Mondello C., Chiesa M., Rebuzzini P., Zongaro S., Verri A.,
RA   Colombo T., Giulotto E., D'Incalci M., Franceschi C., Nuzzo F.;
RT   "Karyotype instability and anchorage-independent growth in
RT   telomerase-immortalized fibroblasts from two centenarian individuals.";
RL   Biochem. Biophys. Res. Commun. 308:914-921(2003).
//
RX   PubMed=16357149; DOI=10.1158/0008-5472.CAN-05-1140;
RA   Zongaro S., de Stanchina E., Colombo T., D'Incalci M., Giulotto E.,
RA   Mondello C.;
RT   "Stepwise neoplastic transformation of a telomerase immortalized
RT   fibroblast cell line.";
RL   Cancer Res. 65:11411-11418(2005).
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RX   PubMed=21209796; DOI=10.1371/journal.pone.0014154; PMCID=PMC3014295;
RA   Belgiovine C., Frapolli R., Bonezzi K., Chiodi I., Favero F.,
RA   Mello-Grand M., Dei Tos A.P., Giulotto E., Taraboletti G.,
RA   D'Incalci M., Mondello C.;
RT   "Reduced expression of the ROCK inhibitor Rnd3 is associated with
RT   increased invasiveness and metastatic potential in mesenchymal tumor
RT   cells.";
RL   PLoS ONE 5:e14154.1-e14154.10(2010).
//