ID   TC71
AC   CVCL_S882
DR   cancercelllines; CVCL_S882
DR   ColonAtlas; TC71
DR   Cosmic; 711259
DR   Cosmic; 887221
DR   Cosmic; 1132567
DR   Cosmic; 1479584
DR   GEO; GSM2550020
DR   Wikidata; Q54971843
RX   PubMed=9000572;
RX   PubMed=10732766;
RX   PubMed=11526487;
RX   PubMed=20570890;
RX   PubMed=24042735;
RX   PubMed=25944804;
RX   PubMed=28683746;
CC   Doubling time: 28.52 hours (PubMed=25944804).
CC   Microsatellite instability: Instable (MSI) (PubMed=9000572; PubMed=24042735; PubMed=28683746).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (PubMed=20570890; PubMed=24042735; PubMed=28683746).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Arg233Ter (c.697C>T); ClinVar=VCV000007813; Zygosity=Heterozygous (PubMed=24042735; PubMed=28683746).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys176Tyr (c.527G>A); ClinVar=VCV000186451; Zygosity=Unspecified (PubMed=28683746).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg213Ter (c.637C>T); ClinVar=VCV000043590; Zygosity=Unspecified (PubMed=28683746).
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; SNP array analysis.
CC   Miscellaneous: STR profile mentioned but not shown in PubMed=24042735; obtained from personal communication of Lind, Guro Elisabeth.
CC   Derived from site: In situ; Colon, sigmoid; UBERON=UBERON_0001159.
ST   Source(s): PubMed=24042735
ST   Amelogenin: X
ST   CSF1PO: 10,15
ST   D13S317: 9,12,13
ST   D16S539: 11
ST   D18S51: 10,11,15
ST   D19S433: 13
ST   D21S11: 29,32.2
ST   D2S1338: 16,17
ST   D3S1358: 15
ST   D5S818: 10,12
ST   D7S820: 12
ST   D8S1179: 10,13
ST   FGA: 18,19
ST   TH01: 7,8
ST   TPOX: 9,11
ST   vWA: 14,17
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 14-08-25; Version: 19
//
RX   PubMed=10732766; DOI=10.1054/bjoc.1999.1019; PMCID=PMC2374412;
RA   Bras-Goncalves, Rui Alberto
RA   Rosty, Christophe
RA   Laurent-Puig, Pierre
RA   Soulie, Priscilla
RA   Dutrillaux, Bernard
RA   Poupon, Marie-France
RT   "Sensitivity to CPT-11 of xenografted human colorectal cancers as a
RT   function of microsatellite instability and p53 status.";
RL   Br. J. Cancer 82:913-923(2000).
//
RX   PubMed=11526487; DOI=10.1038/sj.onc.1204611;
RA   Gayet, Jacqueline
RA   Zhou, Xiao-Ping
RA   Duval, Alex
RA   Rolland, Sandra
RA   Hoang, Jean-Marc
RA   Cottu, Paul-Henri
RA   Hamelin, Richard
RT   "Extensive characterization of genetic alterations in a series of
RT   human colorectal cancer cell lines.";
RL   Oncogene 20:5025-5032(2001).
//
RX   PubMed=20570890; DOI=10.1158/0008-5472.CAN-10-0192; PMCID=PMC2943514;
RA   Janakiraman, Manickam
RA   Vakiani, Efsevia
RA   Zeng, Zhao-Shi
RA   Pratilas, Christine A.
RA   Taylor, Barry Stephen
RA   Chitale, Dhananjay
RA   Halilovic, Ensar
RA   Wilson, Manda
RA   Huberman, Kety
RA   Ricarte Filho, Julio Cezar Marques
RA   Persaud, Yogindra
RA   Levine, Douglas A.
RA   Fagin, James Alexander
RA   Jhanwar, Suresh C.
RA   Mariadason, John M.
RA   Lash, Alex
RA   Ladanyi, Marc
RA   Saltz, Leonard B.
RA   Heguy, Adriana
RA   Paty, Philip B.
RA   Solit, David B.
RT   "Genomic and biological characterization of exon 4 KRAS mutations in
RT   human cancer.";
RL   Cancer Res. 70:5901-5911(2010).
//
RX   PubMed=9000572;
RA   Hoang, Jean-Marc
RA   Cottu, Paul-Henri
RA   Thuille, Benedicte
RA   Salmon, Remi J.
RA   Thomas, Gilles
RA   Hamelin, Richard
RT   "BAT-26, an indicator of the replication error phenotype in colorectal
RT   cancers and cell lines.";
RL   Cancer Res. 57:300-303(1997).
//
RX   PubMed=25944804; DOI=10.1158/1078-0432.CCR-14-2457;
RA   Bazzocco, Sarah
RA   Dopeso, Higinio
RA   Carton-Garcia, Fernando
RA   Macaya, Irati
RA   Andretta, Elena
RA   Chionh, Fiona
RA   Rodrigues, Paulo
RA   Garrido, Miriam
RA   Alazzouzi, Hafid
RA   Nieto, Rocio
RA   Sanchez, Alex
RA   Schwartz, Simo Jr.
RA   Bilic, Josipa
RA   Mariadason, John M.
RA   Arango, Diego
RT   "Highly expressed genes in rapidly proliferating tumor cells as new
RT   targets for colorectal cancer treatment.";
RL   Clin. Cancer Res. 21:3695-3704(2015).
//
RX   PubMed=24042735; DOI=10.1038/oncsis.2013.35; PMCID=PMC3816225;
RA   Ahmed, Deeqa
RA   Eide, Peter W.
RA   Eilertsen, Ina A.
RA   Danielsen, Stine A.
RA   Eknaes, Mette
RA   Hektoen, Merete
RA   Lind, Guro Elisabeth
RA   Lothe, Ragnhild Adelheid
RT   "Epigenetic and genetic features of 24 colon cancer cell lines.";
RL   Oncogenesis 2:e71.1-e71.8(2013).
//
RX   PubMed=28683746; DOI=10.1186/s12943-017-0691-y; PMCID=PMC5498998;
RA   Berg, Kaja Christine Graue
RA   Eide, Peter W.
RA   Eilertsen, Ina A.
RA   Johannessen, Bjarne
RA   Bruun, Jarle
RA   Danielsen, Stine A.
RA   Bjornslett, Merete
RA   Meza-Zepeda, Leonardo Andres
RA   Eknaes, Mette
RA   Lind, Guro Elisabeth
RA   Myklebost, Ola
RA   Skotheim, Rolf Inge
RA   Sveen, Anita
RA   Lothe, Ragnhild Adelheid
RT   "Multi-omics of 34 colorectal cancer cell lines -- a resource for
RT   biomedical studies.";
RL   Mol. Cancer 16:116.1-116.16(2017).
//