ID   HROC87 T0 M2
AC   CVCL_S854
SY   HROC87; HROC87X
DR   cancercelllines; CVCL_S854
DR   CLS; 300831
DR   GEO; GSM1448072
DR   Wikidata; Q54895306
RX   PubMed=23300683;
RX   PubMed=25926053;
RX   PubMed=31601052;
CC   From: Linnebacher M.; University of Rostock; Rostock; Germany.
CC   Population: Caucasian.
CC   Characteristics: Established from a patient-derived xenograft established in female NMRI nu/nu mice.
CC   Doubling time: 26 hours (CLS=300831).
CC   Microsatellite instability: Instable (MSI) (PubMed=25926053).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=23300683).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Colon, ascending; UBERON=UBERON_0001156.
ST   Source(s): CLS=300831; Direct_author_submission; PubMed=25926053
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 10 (Direct_author_submission)
ST   D13S317: 10,14 (CLS=300831; PubMed=25926053)
ST   D16S539: 11,13
ST   D21S11: 28,29
ST   D5S818: 9,11
ST   D7S820: 9
ST   TH01: 8
ST   TPOX: 11,13
ST   vWA: 16,20
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   76Y
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 02-05-24; Version: 23
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RX   PubMed=23300683; DOI=10.1371/journal.pone.0052485;
RA   Maletzki C., Stier S., Gruenert U., Gock M., Ostwald C., Prall F.,
RA   Linnebacher M.;
RT   "Establishment, characterization and chemosensitivity of three
RT   mismatch repair deficient cell lines from sporadic and inherited
RT   colorectal carcinomas.";
RL   PLoS ONE 7:E52485-E52485(2012).
//
RX   PubMed=25926053; DOI=10.1038/ncomms8002;
RA   Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G.,
RA   Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S.,
RA   Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M.,
RA   Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.;
RT   "The molecular landscape of colorectal cancer cell lines unveils
RT   clinically actionable kinase targets.";
RL   Nat. Commun. 6:7002.1-7002.10(2015).
//
RX   PubMed=31601052; DOI=10.3390/cancers11101520;
RA   Mullins C.S., Micheel B., Matschos S., Leuchter M., Burtin F.,
RA   Krohn M., Huhns M., Klar E., Prall F., Linnebacher M.;
RT   "Integrated biobanking and tumor model establishment of human
RT   colorectal carcinoma provides excellent tools for preclinical
RT   research.";
RL   Cancers (Basel) 11:1520.1-1520.18(2019).
//