ID   AY-27
AC   CVCL_S825
SY   AY 27; AY27
DR   Millipore; SCC254
DR   ChEMBL-Cells; CHEMBL4482253
DR   PubChem_Cell_line; CVCL_S825
DR   Wikidata; Q54752001
RX   PubMed=2936252;
RX   PubMed=2981157;
RX   PubMed=7298281;
RX   PubMed=10574249;
RX   PubMed=20404568;
RX   PubMed=21424013;
RX   PubMed=29732388;
CC   Characteristics: Tumorigenic.
CC   Doubling time: 0.927 +- 0.206 days (PubMed=2936252).
CC   Transformant: ChEBI; CHEBI:82328; Nifurthiazole (N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide; FANFT).
CC   Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
CC   Breed/subspecies: Fischer 344.
DI   NCIt; C64161; Transitional cell carcinoma of the rat urinary bladder
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
SX   Male
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 29-06-23; Version: 11
//
RX   PubMed=2936252;
RA   Shulok J.R., Klaunig J.E., Selman S.H., Schafer P.J., Goldblatt P.J.;
RT   "Cellular effects of hematoporphyrin derivative photodynamic therapy
RT   on normal and neoplastic rat bladder cells.";
RL   Am. J. Pathol. 122:277-283(1986).
//
RX   PubMed=2981157;
RA   Chlapowski F.J., Nemecek G.M.;
RT   "Aberrant cyclic adenosine 3':5'-monophosphate metabolism in cultures
RT   of tumorigenic rat urothelium.";
RL   Cancer Res. 45:122-127(1985).
//
RX   PubMed=7298281;
RA   Cohen S.M., Yang J.P.S., Jacobs J.B., Arai M., Fukushima S.,
RA   Friedell G.H.;
RT   "Transplantation and cell culture of rat urinary bladder carcinoma.";
RL   Invest. Urol. 19:136-141(1981).
//
RX   PubMed=10574249; DOI=10.1038/sj.bjc.6690741;
RA   Xiao Z.-W., McCallum T.J., Brown K.M., Miller G.G., Halls S.B.,
RA   Parney I.F., Moore R.B.;
RT   "Characterization of a novel transplantable orthotopic rat bladder
RT   transitional cell tumour model.";
RL   Br. J. Cancer 81:638-646(1999).
//
RX   PubMed=20404568; DOI=10.4161/cbt.9.12.11638;
RA   Vandepitte J., Maes J., Van Cleynenbreugel B., Van Poppel H.,
RA   Lerut E., Agostinis P., de Witte P.A.M.;
RT   "An improved orthotopic rat bladder tumor model using Dil-loaded
RT   fluorescent AY-27 cells.";
RL   Cancer Biol. Ther. 9:986-993(2010).
//
RX   PubMed=21424013; DOI=10.1039/c0pp00393j;
RA   Ekroll I.K., Gederaas O.A., Helander L., Hjelde A., Melo T.B.,
RA   Johnsson A.;
RT   "Photo induced hexylaminolevulinate destruction of rat bladder cells
RT   AY-27.";
RL   Photochem. Photobiol. Sci. 10:1072-1079(2011).
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RX   PubMed=29732388; DOI=10.3233/BLC-180167;
RA   Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D.;
RT   "Systematic review: characteristics and preclinical uses of bladder
RT   cancer cell lines.";
RL   Bladder Cancer 4:169-183(2018).
//