ID   1765-92
AC   CVCL_S817
SY   MLS 1765-92; MLS-1765; MLS1765
DR   Cosmic; 1672268
DR   Cosmic; 2307720
DR   Wikidata; Q54582361
RX   PubMed=16983332;
RX   PubMed=20515481;
RX   PubMed=24726063;
RX   PubMed=25393000;
RX   PubMed=27270875;
CC   Sequence variation: Gene fusion; HGNC; HGNC:2726; DDIT3 + HGNC; HGNC:4010; FUS; Name(s)=FUS-DDIT3, TLS-CHOP (PubMed=27270875).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=27270875).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
DI   NCIt; C27781; Myxoid liposarcoma
DI   ORDO; Orphanet_99967; Myxoid/round cell liposarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
CA   Transformed cell line
DT   Created: 03-02-14; Last updated: 19-12-24; Version: 15
//
RX   PubMed=16983332; DOI=10.1038/sj.onc.1209996;
RA   Candeias M.M., Powell D.J., Roubalova E., Apcher S., Bourougaa K.,
RA   Vojtesek B., Bruzzoni-Giovanelli H., Fahraeus R.;
RT   "Expression of p53 and p53/47 are controlled by alternative mechanisms
RT   of messenger RNA translation initiation.";
RL   Oncogene 25:6936-6947(2006).
//
RX   PubMed=20515481; DOI=10.1186/1471-2407-10-249; PMCID=PMC2889895;
RA   Andersson M.K., Goransson M., Olofsson A., Andersson C., Aman P.;
RT   "Nuclear expression of FLT1 and its ligand PGF in FUS-DDIT3 carrying
RT   myxoid liposarcomas suggests the existence of an intracrine signaling
RT   loop.";
RL   BMC Cancer 10:249.1-249.10(2010).
//
RX   PubMed=24726063; DOI=10.1186/1756-9966-33-33; PMCID=PMC4022359;
RA   Koelsche C., Renner M., Hartmann W., Brandt R., Lehner B.,
RA   Waldburger N., Alldinger I., Schmitt T., Egerer G., Penzel R.,
RA   Wardelmann E., Schirmacher P., von Deimling A., Mechtersheimer G.;
RT   "TERT promoter hotspot mutations are recurrent in myxoid liposarcomas
RT   but rare in other soft tissue sarcoma entities.";
RL   J. Exp. Clin. Cancer Res. 33:33.1-33.8(2014).
//
RX   PubMed=25393000; DOI=10.1371/journal.pone.0113110; PMCID=PMC4231113;
RA   Stahlberg A., Kabjorn-Gustafsson C., Engtrom K., Thomsen C.,
RA   Dolatabadi S., Jonasson E., Li C.-Y., Ruff D., Chen S.-M., Aman P.;
RT   "Normal and functional TP53 in genetically stable myxoid/round cell
RT   liposarcoma.";
RL   PLoS ONE 9:e113110.1-e113110.7(2014).
//
RX   PubMed=27270875; DOI=10.1038/labinvest.2016.64; PMCID=PMC4965313;
RA   de Graaff M.A., Yu J.S.E., Beird H.C., Ingram D.R., Nguyen T.,
RA   Liu J.J.-H., Bolshakov S.V., Szuhai K., Aman P., Torres K.E., Lev D.C.,
RA   Nielsen T.O., Bovee J.V.M.G., Lazar A.J.F., Somaiah N.;
RT   "Establishment and characterization of a new human myxoid liposarcoma
RT   cell line (DL-221) with the FUS-DDIT3 translocation.";
RL   Lab. Invest. 96:885-894(2016).
//