ID   2645-94
AC   CVCL_S816
SY   MLS 2645-94
DR   EFO; EFO_0022654
DR   PRIDE; PXD012680
DR   Wikidata; Q54583682
RX   PubMed=10449603;
RX   PubMed=16651630;
RX   PubMed=20515481;
RX   PubMed=25393000;
RX   PubMed=30962207;
CC   Sequence variation: Gene fusion; HGNC; HGNC:2726; DDIT3 + HGNC; HGNC:4010; FUS; Name(s)=FUS-DDIT3, TLS-CHOP (PubMed=16651630).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
DI   NCIt; C27781; Myxoid liposarcoma
DI   ORDO; Orphanet_99967; Myxoid/round cell liposarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
CA   Transformed cell line
DT   Created: 03-02-14; Last updated: 19-12-24; Version: 12
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RX   PubMed=10449603; DOI=10.1002/(SICI)1097-0215(19990924)83:1<30::AID-IJC6>3.0.CO;2-4;
RA   Thelin-Jarnum S., Lassen C., Panagopoulos I., Mandahl N., Aman P.;
RT   "Identification of genes differentially expressed in TLS-CHOP carrying
RT   myxoid liposarcomas.";
RL   Int. J. Cancer 83:30-33(1999).
//
RX   PubMed=16651630; DOI=10.2353/ajpath.2006.050872; PMCID=PMC1606602;
RA   Engstrom K., Willen H., Kabjorn-Gustafsson C., Andersson C.,
RA   Olsson M., Goransson M., Thelin-Jarnum S., Olofsson A., Warnhammar E.,
RA   Aman P.;
RT   "The myxoid/round cell liposarcoma fusion oncogene FUS-DDIT3 and the
RT   normal DDIT3 induce a liposarcoma phenotype in transfected human
RT   fibrosarcoma cells.";
RL   Am. J. Pathol. 168:1642-1653(2006).
//
RX   PubMed=20515481; DOI=10.1186/1471-2407-10-249; PMCID=PMC2889895;
RA   Andersson M.K., Goransson M., Olofsson A., Andersson C., Aman P.;
RT   "Nuclear expression of FLT1 and its ligand PGF in FUS-DDIT3 carrying
RT   myxoid liposarcomas suggests the existence of an intracrine signaling
RT   loop.";
RL   BMC Cancer 10:249.1-249.10(2010).
//
RX   PubMed=25393000; DOI=10.1371/journal.pone.0113110; PMCID=PMC4231113;
RA   Stahlberg A., Kabjorn-Gustafsson C., Engtrom K., Thomsen C.,
RA   Dolatabadi S., Jonasson E., Li C.-Y., Ruff D., Chen S.-M., Aman P.;
RT   "Normal and functional TP53 in genetically stable myxoid/round cell
RT   liposarcoma.";
RL   PLoS ONE 9:e113110.1-e113110.7(2014).
//
RX   PubMed=30962207; DOI=10.15252/embr.201845766; PMCID=PMC6500973;
RA   Linden M., Thomsen C., Grundevik P., Jonasson E., Andersson D.,
RA   Runnberg R., Dolatabadi S., Vannas C., Santamaria M.L.,
RA   Fagman H., Stahlberg A., Aman P.;
RT   "FET family fusion oncoproteins target the SWI/SNF chromatin
RT   remodeling complex.";
RL   EMBO Rep. 20:e45766.1-e45766.15(2019).
//