ID   HCC4006/R
AC   CVCL_S746
SY   HCC4006R; HCC4006/ER; HCC4006ER
DR   cancercelllines; CVCL_S746
DR   Cosmic; 1890457
DR   Cosmic; 2015232
DR   Wikidata; Q54881727
RX   PubMed=22773810;
RX   PubMed=23733853;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_114785; Erlotinib.
CC   Sequence variation: Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Leu747_Glu749del (c.2239_2247delTAAGAGAA); ClinVar=VCV000177765; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr205His (c.613T>C); ClinVar=VCV000376685; Zygosity=Homozygous (from parent cell line).
CC   Omics: Genomics; Whole exome sequencing.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
CC   Cell type: Epithelial cell; CL=CL_0000066.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1269 ! HCC4006
SX   Male
AG   >50Y
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 14-08-25; Version: 19
//
RX   PubMed=23733853; DOI=10.1101/gr.152322.112; PMCID=PMC3759720;
RA   Jia, Pei-Lin
RA   Jin, Hai-Ling
RA   Meador, Catherine Belle
RA   Xia, Jun-Feng
RA   Ohashi, Kadoaki
RA   Liu, Lin
RA   Pirazzoli, Valentina
RA   Dahlman, Kimberly Brown
RA   Politi, Katerina
RA   Michor, Franziska
RA   Zhao, Zhong-Ming
RA   Pao, William
RT   "Next-generation sequencing of paired tyrosine kinase
RT   inhibitor-sensitive and -resistant EGFR mutant lung cancer cell lines
RT   identifies spectrum of DNA changes associated with drug resistance.";
RL   Genome Res. 23:1434-1445(2013).
//
RX   PubMed=22773810; DOI=10.1073/pnas.1203530109; PMCID=PMC3411967;
RA   Ohashi, Kadoaki
RA   Sequist, Lecia VanDam
RA   Arcila, Maria E.
RA   Moran, Teresa
RA   Chmielecki, Juliann
RA   Lin, Ya-Lun
RA   Pan, Yu-Mei
RA   Wang, Lu
RA   de Stanchina, Elisa
RA   Shien, Kazuhiko
RA   Aoe, Keisuke
RA   Toyooka, Shinichi
RA   Kiura, Katsuyuki
RA   Fernandez-Cuesta, Lynnette
RA   Fidias, Panos
RA   Yang, James Chih-Hsin
RA   Miller, Vincent A.
RA   Riely, Gregory J.
RA   Kris, Mark G.
RA   Engelman, Jeffrey Adam
RA   Vnencak-Jones, Cindy L.
RA   Dias-Santagata, Dora
RA   Ladanyi, Marc
RA   Pao, William
RT   "Lung cancers with acquired resistance to EGFR inhibitors occasionally
RT   harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or
RT   MEK1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:E2127-E2133(2012).
//