ID   ORL-48
AC   CVCL_S692
SY   ORL-48T; 48T
DR   BioGRID_ORCS_Cell_line; 1270
DR   cancercelllines; CVCL_S692
DR   Cell_Model_Passport; SIDM01987
DR   Cosmic; 2296300
DR   Cosmic; 2531640
DR   Cosmic; 2559734
DR   IARC_TP53; 25069
DR   Wikidata; Q54936492
RX   PubMed=17273794;
RX   PubMed=24224046;
RX   PubMed=25275298;
RX   PubMed=27050151;
RX   PubMed=32990596;
CC   Part of: OPC-22 oral and pharyngeal cancer cell line panel.
CC   Population: Indian; Sikh.
CC   Microsatellite instability: Stable (MSS) (PubMed=17273794).
CC   Sequence variation: Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Thr3033Asnfs*11 (c.9097dupA); ClinVar=VCV000038208; Zygosity=Unspecified (PubMed=27050151).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu294Serfs*51 (c.876delA) (p.Phe292fs); Zygosity=Unspecified (PubMed=17273794; PubMed=24224046; PubMed=27050151).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu336Ter (c.1006G>T); Zygosity=Unspecified (PubMed=17273794; PubMed=24224046; PubMed=27050151).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; CRISPR screening.
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: In situ; Oral cavity, gingiva; UBERON=UBERON_0001828.
ST   Source(s): PubMed=25275298; PubMed=27050151
ST   Amelogenin: X
ST   CSF1PO: 10 (PubMed=25275298)
ST   CSF1PO: 10,11 (PubMed=27050151)
ST   D13S317: 12
ST   D16S539: 11,13
ST   D18S51: 14
ST   D19S433: 13
ST   D21S11: 29,32.2
ST   D2S1338: 19,25
ST   D3S1358: 15
ST   D5S818: 11 (PubMed=25275298)
ST   D5S818: 11,12 (PubMed=27050151)
ST   D7S820: 11
ST   D8S1179: 12,15
ST   FGA: 24,25
ST   Penta D: 9,11
ST   Penta E: 7,18
ST   TH01: 6,9
ST   TPOX: 11
ST   vWA: 19
DI   NCIt; C129857; Gingival squamous cell carcinoma
DI   ORDO; Orphanet_502363; Squamous cell carcinoma of the oral cavity
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   79Y
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 10-04-25; Version: 19
//
RX   PubMed=17273794; DOI=10.3892/ijmm.19.3.453;
RA   Hamid S., Lim K.P., Zain R.B., Ismail S.M., Lau S.H., Mustafa W.M.W.,
RA   Abraham M.T., Nam N.A., Teo S.-H., Cheong S.-C.;
RT   "Establishment and characterization of Asian oral cancer cell lines as
RT   in vitro models to study a disease prevalent in Asia.";
RL   Int. J. Mol. Med. 19:453-460(2007).
//
RX   PubMed=24224046; DOI=10.1371/journal.pone.0080229; PMCID=PMC3817115;
RA   Zanaruddin S.N.S., Yee P.-S., Hor S.Y., Kong Y.H., Ghani W.M.N.W.A.,
RA   Mustafa W.M.W., Zain R.B., Prime S.S., Rahman Z.A.A., Cheong S.-C.;
RT   "Common oncogenic mutations are infrequent in oral squamous cell
RT   carcinoma of Asian origin.";
RL   PLoS ONE 8:e80229.1-e80229.12(2013).
//
RX   PubMed=25275298; DOI=10.18632/oncotarget.2417; PMCID=PMC4253406;
RA   Martin D., Abba M.C., Molinolo A.A., Vitale-Cross L., Wang Z.-Y.,
RA   Zaida M., Delic N.C., Samuels Y., Lyons J.G., Gutkind J.S.;
RT   "The head and neck cancer cell oncogenome: a platform for the
RT   development of precision molecular therapies.";
RL   Oncotarget 5:8906-8923(2014).
//
RX   PubMed=27050151; DOI=10.18632/oncotarget.8533; PMCID=PMC5053689;
RA   Fadlullah M.Z.H., Chiang I.K.-N., Dionne K.R., Yee P.-S., Gan C.P.,
RA   Sam K.K., Tiong K.H., Ng A.K.W., Martin D., Lim K.P., Kallarakkal T.G.,
RA   Mustafa W.M.W., Lau S.H., Abraham M.T., Zain R.B., Rahman Z.A.A.,
RA   Molinolo A.A., Patel V., Gutkind J.S., Tan A.-C., Cheong S.-C.;
RT   "Genetically-defined novel oral squamous cell carcinoma cell lines for
RT   the development of molecular therapies.";
RL   Oncotarget 7:27802-27818(2016).
//
RX   PubMed=32990596; DOI=10.7554/eLife.57761; PMCID=PMC7591259;
RA   Chai A.W.-Y., Yee P.-S., Price S., Yee S.-M., Lee H.-M., Tiong V.K.H.,
RA   Goncalves E., Behan F.M., Bateson J., Gilbert J.G.R., Tan A.-C.,
RA   McDermott U., Garnett M.J., Cheong S.-C.;
RT   "Genome-wide CRISPR screens of oral squamous cell carcinoma reveal
RT   fitness genes in the Hippo pathway.";
RL   eLife 9:e57761.1-e57761.34(2020).
//