ID   A3R5.7
AC   CVCL_S540
SY   A3.01/R5.7; A3R5
DR   cancercelllines; CVCL_S540
DR   HIVReagentProgram; ARP-12386
DR   Wikidata; Q54606881
RX   PubMed=24312168;
RX   PubMed=24607608;
CC   Population: Caucasian.
CC   Characteristics: Expresses CCR5 under the control of a CMV promoter (PubMed=24312168).
CC   Characteristics: Useful for the detection of weak neutralizing antibody responses against tier 2 strains of HIV-1 (PubMed=24607608).
CC   Sequence variation: Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: HGNC; 1606; CCR5.
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_6244 ! CEM A3.01
SX   Female
AG   3Y11M
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 05-10-23; Version: 12
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RX   PubMed=24312168; DOI=10.1371/journal.pone.0077756;
RA   McLinden R.J., LaBranche C.C., Chenine A.-L., Polonis V.R., Eller M.A.,
RA   Wieczorek L., Ochsenbauer-Jambor C., Kappes J.C., Perfetto S.,
RA   Montefiori D.C., Michael N.L., Kim J.H.;
RT   "Detection of HIV-1 neutralizing antibodies in a human
RT   CD4(+)/CXCR4(+)/CCR5(+) T-lymphoblastoid cell assay system.";
RL   PLoS ONE 8:E77756-E77756(2013).
//
RX   PubMed=24607608; DOI=10.1016/j.jim.2014.02.013;
RA   Sarzotti-Kelsoe M., Daniell X.-J., Todd C.A., Bilska M., Martelli A.,
RA   LaBranche C.C., Perez L.G., Ochsenbauer-Jambor C., Kappes J.C.,
RA   Rountree W., Denny T.N., Montefiori D.C.;
RT   "Optimization and validation of a neutralizing antibody assay for
RT   HIV-1 in A3R5 cells.";
RL   J. Immunol. Methods 409:147-160(2014).
//