ID   R06E
AC   CVCL_S504
SY   R-06E; RO6E; AGE1.R06E; AGE1.RO
DR   BEI_Resources; NR-49168
DR   DSMZ; ACC-756
DR   DSMZCellDive; ACC-756
DR   Wikidata; Q54948982
RX   Patent=US8679839;
RX   PubMed=19540275;
RX   PubMed=20808767;
RX   PubMed=22754654;
RX   PubMed=33389257;
CC   Group: Bat cell line.
CC   Group: Patented cell line.
CC   Problematic cell line: Partially contaminated. Some cultures of R06E are contaminated with the Vero cell line (PubMed=22754654), this is the case of the culture used in PubMed=20808767.
CC   From: ProBioGen AG; Berlin; Germany.
CC   Registration: International Depositary Authority, Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ); ACC-2902.
CC   Virology: Not susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=33389257).
CC   Doubling time: ~50 hours (PubMed=19540275); ~40 hours (DSMZ=ACC-756).
CC   Transformant: NCBI_TaxID; 28285; Adenovirus 5 [Note=E1].
OX   NCBI_TaxID=9407; ! Rousettus aegyptiacus (Egyptian rousette)
OI   CVCL_Z551 ! R05R
SX   Sex unspecified
AG   Fetus
CA   Transformed cell line
DT   Created: 03-02-14; Last updated: 05-10-23; Version: 16
RX   Patent=US8679839;
RA   Jordan I., Horn D., Sandig V.;
RT   "Cell line from Rousettus as host cell for pathogen amplification.";
RL   Patent number US8679839, 25-Mar-2014.
RX   PubMed=19540275; DOI=10.1016/j.virusres.2009.06.007;
RA   Jordan I., Horn D., Oehmke S., Leendertz F.H., Sandig V.;
RT   "Cell lines from the Egyptian fruit bat are permissive for modified
RT   vaccinia Ankara.";
RL   Virus Res. 145:54-62(2009).
RX   PubMed=20808767; DOI=10.1371/journal.pntd.0000802;
RA   Krahling V., Dolnik O., Kolesnikova L., Schmidt-Chanasit J.,
RA   Jordan I., Sandig V., Gunther S., Becker S.;
RT   "Establishment of fruit bat cells (Rousettus aegyptiacus) as a model
RT   system for the investigation of filoviral infection.";
RL   PLoS Negl. Trop. Dis. 4:e802.1-e802.9(2010).
RX   PubMed=22754654; DOI=10.3390/v4050889;
RA   Jordan I., Munster V.J., Sandig V.;
RT   "Authentication of the R06E fruit bat cell line.";
RL   Viruses 4:889-900(2012).
RX   PubMed=33389257; DOI=10.1007/s10096-020-04106-0;
RA   Wurtz N., Penant G., Jardot P., Duclos N., La Scola B.;
RT   "Culture of SARS-CoV-2 in a panel of laboratory cell lines,
RT   permissivity, and differences in growth profile.";
RL   Eur. J. Clin. Microbiol. Infect. Dis. 40:477-484(2021).