ID   A549-Mx2/EGFP L2G9
AC   CVCL_RX09
SY   A549L2G9; A549 L2G9; L2G9
DR   cancercelllines; CVCL_RX09
DR   Wikidata; Q54607001
RX   PubMed=22373148;
RX   PubMed=27346232;
CC   Population: Caucasian.
CC   Biotechnology: Used for a reporter gene assay (RGA) of the human type 1 interferon potency (PubMed=27346232).
CC   Characteristics: Expression of eGFP is under the control of the control of the mouse Mx2 promoter (PubMed=27346232).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (from parent cell line).
CC   Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0023 ! A-549
SX   Male
AG   58Y
CA   Cancer cell line
DT   Created: 05-03-18; Last updated: 05-10-23; Version: 10
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RX   PubMed=22373148; DOI=10.1186/1753-6561-5-S8-P4;
RA   Burgi M., Prieto C., Oggero M., Bollati-Fogolin M.,
RA   Etcheverrigaray M., Kratje R.;
RT   "New reporter cell clones to determine the biological activity of
RT   human type I interferons.";
RL   BMC Proc. 5 Suppl. 8:P4-P4(2011).
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RX   PubMed=27346232; DOI=10.1016/j.jbiotec.2016.06.021;
RA   Burgi M., Zapol'skii V.A., Hinkelmann B., Koster M., Kaufmann D.E.,
RA   Sasse F., Hauser H., Etcheverrigaray M., Kratje R.,
RA   Bollati-Fogolin M., Oggero M.;
RT   "Screening and characterization of molecules that modulate the
RT   biological activity of IFNs-I.";
RL   J. Biotechnol. 233:6-16(2016).
//