ID   BT012
AC   CVCL_RU28
SY   BT12; BT-12
DR   GEO; GSM2155019
DR   GEO; GSM2155022
DR   Wikidata; Q54798479
RX   PubMed=19544433;
RX   PubMed=20388696;
RX   PubMed=20593219;
RX   PubMed=26095605;
RX   PubMed=27006494;
CC   Group: Cancer stem cell line.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: In situ; Brain; UBERON=UBERON_0000955.
DI   NCIt; C3058; Glioblastoma
DI   ORDO; Orphanet_360; Glioblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   59Y
CA   Cancer cell line
DT   Created: 05-03-18; Last updated: 10-04-25; Version: 7
//
RX   PubMed=19544433; DOI=10.1002/stem.98;
RA   Kelly J.J.P., Stechishin O.D.M., Chojnacki A., Lun X.-Q., Sun B.-C.,
RA   Senger D.L., Forsyth P., Auer R.N., Dunn J.F., Cairncross J.G.,
RA   Parney I.F., Weiss S.;
RT   "Proliferation of human glioblastoma stem cells occurs independently
RT   of exogenous mitogens.";
RL   Stem Cells 27:1722-1733(2009).
//
RX   PubMed=20388696; DOI=10.1093/neuonc/noq031; PMCID=PMC2940664;
RA   Kelly J.J.P., Blough M.D., Stechishin O.D.M., Chan J.A.-W.,
RA   Beauchamp D.C., Perizzolo M., Demetrick D.J., Steele L., Auer R.N.,
RA   Hader W.J., Westgate M.R., Parney I.F., Jenkins R.B., Cairncross J.G.,
RA   Weiss S.;
RT   "Oligodendroglioma cell lines containing t(1;19)(q10;p10).";
RL   Neuro-oncol. 12:745-755(2010).
//
RX   PubMed=20593219; DOI=10.1007/s11060-010-0283-9;
RA   Blough M.D., Beauchamp D.C., Westgate M.R., Kelly J.J.P.,
RA   Cairncross J.G.;
RT   "Effect of aberrant p53 function on temozolomide sensitivity of glioma
RT   cell lines and brain tumor initiating cells from glioblastoma.";
RL   J. Neurooncol. 102:1-7(2011).
//
RX   PubMed=26095605; DOI=10.1016/j.stemcr.2015.05.010; PMCID=PMC4618251;
RA   Cusulin C., Chesnelong C., Bose P., Bilenky M., Kopciuk K., Chan J.A.-W.,
RA   Cairncross J.G., Jones S.J.M., Marra M.A., Luchman H.A., Weiss S.;
RT   "Precursor states of brain tumor initiating cell lines are predictive
RT   of survival in xenografts and associated with glioblastoma
RT   subtypes.";
RL   Stem Cell Reports 5:1-9(2015).
//
RX   PubMed=27006494; DOI=10.1158/1078-0432.CCR-15-1798;
RA   Lun X.-Q., Wells J.C., Grinshtein N., King J.C., Hao X.-G., Dang N.-H.,
RA   Wang X.-L., Aman A., Uehling D., Datti A., Wrana J.L., Easaw J.C.,
RA   Luchman H.A., Weiss S., Cairncross J.G., Kaplan D.R., Robbins S.M.,
RA   Senger D.L.;
RT   "Disulfiram when combined with copper enhances the therapeutic effects
RT   of temozolomide for the treatment of glioblastoma.";
RL   Clin. Cancer Res. 22:3860-3875(2016).
//