ID   PPT2
AC   CVCL_RU11
DR   cancercelllines; CVCL_RU11
DR   Millipore; SCC104
DR   Wikidata; Q54947804
RX   PubMed=24086245;
CC   Problematic cell line: Contaminated. Shown to be a HCT 116 derivative (STR profile). Originally thought to originate from a male patient with prostate carcinoma.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1101; BRCA2; Simple; p.Ile2675Aspfs*6 (c.8021dupA) (c.8021_8022insA); ClinVar=VCV000267050; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg24Serfs*20 (c.68dupG) (c.68_69insG) (p.G23fs); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3373; EP300; Simple; p.Met1470Cysfs*22 (c.4408delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9277; PPM1D; Simple; p.Leu450Ter (c.1349delT) (p.Leu450fs) (c.1344delT); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
CC   Discontinued: Millipore; SCC104; true.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
ST   Source(s): Millipore=SCC104
ST   Amelogenin: X
ST   CSF1PO: 7,10
ST   D13S317: 10,11,13
ST   D16S539: 11,13,14
ST   D18S51: 17,18
ST   D21S11: 29,30
ST   D3S1358: 12,18,19
ST   D5S818: 10,11
ST   D7S820: 11,12
ST   D8S1179: 12,14
ST   FGA: 18,22,23
ST   Penta D: 9,13
ST   Penta E: 13,14
ST   TH01: 8,9
ST   TPOX: 8
ST   vWA: 17,18,21,22
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0291 ! HCT 116
SX   Male
AG   48Y
CA   Cancer cell line
DT   Created: 05-03-18; Last updated: 02-05-24; Version: 10
//
RX   PubMed=24086245; DOI=10.1371/journal.pone.0069884; PMCID=PMC3782470;
RA   Botchkina G.I., Zuniga E.S., Rowehl R.A., Park R., Bhalla R.,
RA   Bialkowska A.B., Johnson F., Golub L.M., Zhang Y., Ojima I.,
RA   Shroyer K.R.;
RT   "Prostate cancer stem cell-targeted efficacy of a new-generation
RT   taxoid, SBT-1214 and novel polyenolic zinc-binding curcuminoid,
RT   CMC2.24.";
RL   PLoS ONE 8:E69884-E69884(2013).
//