ID   PPT2
AC   CVCL_RU11
DR   cancercelllines; CVCL_RU11
DR   Millipore; SCC104
DR   Wikidata; Q54947804
RX   PubMed=24086245;
CC   Problematic cell line: Contaminated. Shown to be a HCT 116 derivative (STR profile). Originally thought to originate from a male patient with prostate carcinoma.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Ile2675Aspfs*6 (c.8021dupA) (c.8021_8022insA); ClinVar=VCV000267050; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg24Serfs*20 (c.68dupG) (c.68_69insG) (p.G23fs); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45del (c.133_135delTCT); ClinVar=VCV000017576; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3373; EP300; Simple; p.Met1470Cysfs*22 (c.4408delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3373; EP300; Simple; p.Asn1700Thrfs*9 (c.5099delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Leu450Ter (c.1349delT) (p.Leu450fs) (c.1344delT); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Homozygous (from parent cell line).
CC   Discontinued: Millipore; SCC104; true.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
ST   Source(s): Millipore=SCC104
ST   Amelogenin: X
ST   CSF1PO: 7,10
ST   D13S317: 10,11,13
ST   D16S539: 11,13,14
ST   D18S51: 17,18
ST   D21S11: 29,30
ST   D3S1358: 12,18,19
ST   D5S818: 10,11
ST   D7S820: 11,12
ST   D8S1179: 12,14
ST   FGA: 18,22,23
ST   Penta D: 9,13
ST   Penta E: 13,14
ST   TH01: 8,9
ST   TPOX: 8
ST   vWA: 17,18,21,22
DI   NCIt; C4910; Colon carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0291 ! HCT 116
SX   Male
AG   48Y
CA   Cancer cell line
DT   Created: 05-03-18; Last updated: 19-12-24; Version: 11
//
RX   PubMed=24086245; DOI=10.1371/journal.pone.0069884; PMCID=PMC3782470;
RA   Botchkina, Galina I.
RA   Zuniga, Edison S.
RA   Rowehl, Rebecca A.
RA   Park, Rosa
RA   Bhalla, Rahuldev
RA   Bialkowska, Agnieszka B.
RA   Johnson, Francis
RA   Golub, Lorne M.
RA   Zhang, Yu
RA   Ojima, Iwao
RA   Shroyer, Kenneth Reed
RT   "Prostate cancer stem cell-targeted efficacy of a new-generation
RT   taxoid, SBT-1214 and novel polyenolic zinc-binding curcuminoid,
RT   CMC2.24.";
RL   PLoS ONE 8:e69884.1-e69884.16(2013).
//