ID   RVH-421rPLX4720_10muM
AC   CVCL_RR54
SY   RVH-421rPLX4720(10muM)
DR   cancercelllines; CVCL_RR54
DR   Wikidata; Q54951479
WW   https://www.wass-michaelislab.org/rccl.php
CC   Part of: Resistant Cancer Cell Line (RCCL) collection.
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:63637; Vemurafenib (Zelboraf; PLX4032).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Gln52fs*71 (c.154delC); Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Brain; UBERON=UBERON_0000955.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1672 ! RVH-421
SX   Male
AG   28Y
CA   Cancer cell line
DT   Created: 05-03-18; Last updated: 05-10-23; Version: 12
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