ID   Rh30rVCR10
AC   CVCL_RR39
DR   cancercelllines; CVCL_RR39
DR   Wikidata; Q54950342
RX   PubMed=19147553;
RX   PubMed=25749379;
WW   https://www.wass-michaelislab.org/rccl.php
CC   Part of: Resistant Cancer Cell Line (RCCL) collection.
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:28445; Vincristine (VCR).
CC   Sequence variation: Gene fusion; HGNC; 3819; FOXO1 + HGNC; 8617; PAX3; Name(s)=PAX3-FOXO1, PAX3-FKHR (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9864; RARA; Simple; p.Pro9Leu (c.26C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr205Cys (c.614A>G); ClinVar=VCV000376681; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Heterozygous (PubMed=19147553; PubMed=25749379).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg280Ser (c.840A>T); ClinVar=VCV000988616; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C3749; Alveolar rhabdomyosarcoma
DI   ORDO; Orphanet_99756; Alveolar rhabdomyosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0041 ! Rh30
SX   Male
AG   17Y
CA   Cancer cell line
DT   Created: 05-03-18; Last updated: 05-10-23; Version: 13
//
RX   PubMed=19147553; DOI=10.1158/0008-5472.CAN-08-1856;
RA   Michaelis M., Rothweiler F., Klassert D., von Deimling A., Weber K.,
RA   Fehse B., Kammerer B., Doerr H.-W., Cinatl J. Jr.;
RT   "Reversal of P-glycoprotein-mediated multidrug resistance by the
RT   murine double minute 2 antagonist nutlin-3.";
RL   Cancer Res. 69:416-421(2009).
//
RX   PubMed=25749379; DOI=10.18632/oncotarget.2889;
RA   Michaelis M., Rothweiler F., Loschmann N., Sharifi M., Ghafourian T.,
RA   Cinatl J. Jr.;
RT   "Enzastaurin inhibits ABCB1-mediated drug efflux independently of
RT   effects on protein kinase C signalling and the cellular p53 status.";
RL   Oncotarget 6:17605-17620(2015).
//