ID   HAP1 KDM1A (-) 1
AC   CVCL_RK67
SY   HZGHC000509c010; KDM1A knockout cell line 10bp deletion; HAP1-LSD1-
DR   ArrayExpress; E-MTAB-7061
DR   Horizon_Discovery; HZGHC000509c010
DR   PRIDE; PXD010335
DR   Wikidata; Q54875918
RX   PubMed=29205263;
RX   PubMed=31659326;
CC   Group: Haploid karyotype cell line.
CC   Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:29079; KDM1A.
CC   Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 13 fused to ABL1 exon 2 (b2a2 transcript) (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser215Gly (c.643A>G); ClinVar=VCV000265337; Zygosity=Hemizygous (from parent cell line).
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C3174; Chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_Y019 ! HAP1
SX   Male
AG   40Y
CA   Cancer cell line
DT   Created: 05-03-18; Last updated: 10-04-25; Version: 14
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RX   PubMed=29205263; DOI=10.1111/bjh.14983;
RA   Sonnemann J., Zimmermann M., Marx C., Ebert F., Becker S.,
RA   Lauterjung M.-L., Beck J.F.;
RT   "LSD1 (KDM1A)-independent effects of the LSD1 inhibitor SP2509 in
RT   cancer cells.";
RL   Br. J. Haematol. 183:494-497(2018).
//
RX   PubMed=31659326; DOI=10.1038/s41592-019-0614-5;
RA   Smits A.H., Ziebell F., Joberty G., Zinn N., Mueller W.F.,
RA   Clauder-Munster S., Eberhard D., Falth Savitski M., Grandi P.,
RA   Jakob P., Michon A.-M., Sun H., Tessmer K., Burckstummer T.,
RA   Bantscheff M., Steinmetz L.M., Drewes G., Huber W.;
RT   "Biological plasticity rescues target activity in CRISPR knock outs.";
RL   Nat. Methods 16:1087-1093(2019).
//