ID   MDA-MB-468 shPARG
AC   CVCL_RA91
SY   shPARG MDA-MB-468
DR   cancercelllines; CVCL_RA91
DR   Wikidata; Q54904644
RX   PubMed=29166620;
CC   Group: Triple negative breast cancer (TNBC) cell line.
CC   Population: African American.
CC   Knockout cell: Method=shRNA knockdown; HGNC; HGNC:8605; PARG.
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; c.253+1G>T; ClinVar=VCV000189475; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9884; RB1; Simple; c.265_2787del2523; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
CC   Omics: Proteomics; PTM; Poly-ADP-ribosylation.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C5214; Breast adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0419 ! MDA-MB-468
SX   Female
AG   51Y
CA   Cancer cell line
DT   Created: 05-03-18; Last updated: 10-04-25; Version: 15
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RX   PubMed=29166620; DOI=10.1016/j.celrep.2017.10.106; PMCID=PMC5728415;
RA   Zhen, Yuan-Li
RA   Zhang, Ya-Jie
RA   Yu, Yong-Hao
RT   "A cell-line-specific atlas of PARP-mediated protein
RT   Asp/Glu-ADP-ribosylation in breast cancer.";
RL   Cell Rep. 21:2326-2337(2017).
//