ID   HaCaT siYAP
AC   CVCL_QX09
SY   siYAP_HaCAT
DR   GEO; GSM2112560
DR   GEO; GSM2112561
DR   GEO; GSM2112562
DR   Wikidata; Q54872313
RX   PubMed=26989177;
CC   Population: Caucasian.
CC   Knockout cell: Method=siRNA knockdown; HGNC; HGNC:16262; YAP1.
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.His179Tyr (c.535C>T); ClinVar=VCV000127815; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg282Trp (c.843_844CC>TT); Zygosity=Heterozygous (from parent cell line).
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: In situ; Back, skin, epidermis; UBERON=UBERON_0001068+UBERON_0001003.
CC   Cell type: Keratinocyte; CL=CL_0000312.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0038 ! HaCaT
SX   Male
AG   62Y
CA   Spontaneously immortalized cell line
DT   Created: 15-11-17; Last updated: 10-04-25; Version: 12
//
RX   PubMed=26989177; DOI=10.1242/dev.133728; PMCID=PMC4874484;
RA   Elbediwy, Ahmed
RA   Vincent-Mistiaen, Zoe I.
RA   Spencer-Dene, Bradley
RA   Stone, Richard K.
RA   Boeing, Stefan
RA   Wculek, Stefanie Kristin
RA   Cordero, Julia
RA   Tan, Ee H.
RA   Ridgway, Rachel
RA   Brunton, Valerie G.
RA   Sahai, Erik
RA   Gerhardt, Holger
RA   Behrens, Axel
RA   Malanchi, Ilaria
RA   Sansom, Owen James
RA   Thompson, Barry James
RT   "Integrin signalling regulates YAP and TAZ to control skin
RT   homeostasis.";
RL   Development 143:1674-1687(2016).
//