ID   KK124
AC   CVCL_N704
SY   KK 124
DR   cancercelllines; CVCL_N704
DR   Wikidata; Q54899978
RX   PubMed=1325212;
RX   PubMed=3018508;
RX   PubMed=3026973;
RX   PubMed=3100061;
RX   PubMed=6243721;
RX   PubMed=6243722;
RX   PubMed=6265077;
RX   PubMed=6286763;
RX   PubMed=8176200;
RX   PubMed=8220424;
RX   PubMed=8344493;
RX   PubMed=8568269;
RX   PubMed=9192833;
RX   PubMed=9973220;
RX   PubMed=24590883;
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Unspecified (PubMed=8344493).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Caution: It is possible that KK124 and KK125 (Cellosaurus=CVCL_B495) are the same cell line.
CC   Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
CC   Cell type: B-cell; CL=CL_0000236.
DI   NCIt; C27694; EBV-related Burkitt lymphoma
DI   ORDO; Orphanet_543; Burkitt lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_B495 ! KK125
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 19-12-24; Version: 21
//
RX   PubMed=1325212; DOI=10.1182/blood.V80.5.1289.1289;
RA   Benjamin D., Knobloch T.J., Dayton M.A.;
RT   "Human B-cell interleukin-10: B-cell lines derived from patients with
RT   acquired immunodeficiency syndrome and Burkitt's lymphoma
RT   constitutively secrete large quantities of interleukin-10.";
RL   Blood 80:1289-1298(1992).
//
RX   PubMed=3018508; DOI=10.1128/mcb.5.11.3199-3207.1985; PMCID=PMC369135;
RA   Denny C.T., Hollis G.F., Magrath I.T., Kirsch I.R.;
RT   "Burkitt lymphoma cell line carrying a variant translocation creates
RT   new DNA at the breakpoint and violates the hierarchy of immunoglobulin
RT   gene rearrangement.";
RL   Mol. Cell. Biol. 5:3199-3207(1985).
//
RX   PubMed=3026973; DOI=10.1002/ijc.2910390215;
RA   Ehlin-Henriksson B., Manneborg-Sandlund A., Klein G.;
RT   "Expression of B-cell-specific markers in different Burkitt lymphoma
RT   subgroups.";
RL   Int. J. Cancer 39:211-218(1987).
//
RX   PubMed=3100061; DOI=10.1016/0008-8749(86)90099-7;
RA   Benjamin D., Bazar L.S., Wallace B., Jacobson R.J.;
RT   "Heterogeneity of B-cell growth factor receptor reactivity in healthy
RT   donors and in patients with chronic lymphatic leukemia: relationship
RT   to B-cell-derived lymphokines.";
RL   Cell. Immunol. 103:394-408(1986).
//
RX   PubMed=6243721; DOI=10.1093/jnci/64.3.465;
RA   Magrath I.T., Pizzo P.A., Whang-Peng J., Douglass E.C., Alabaster O.,
RA   Gerber P., Freeman C.B., Novikovs L.;
RT   "Characterization of lymphoma-derived cell lines: comparison of cell
RT   lines positive and negative for Epstein-Barr virus nuclear antigen. I.
RT   Physical, cytogenetic, and growth characteristics.";
RL   J. Natl. Cancer Inst. 64:465-476(1980).
//
RX   PubMed=6243722; DOI=10.1093/jnci/64.3.477;
RA   Magrath I.T., Freeman C.B., Pizzo P.A., Gadek J., Jaffe E.S.,
RA   Santaella M., Hammer C., Frank M.M., Reaman G., Novikovs L.;
RT   "Characterization of lymphoma-derived cell lines: comparison of cell
RT   lines positive and negative for Epstein-Barr virus nuclear antigen.
RT   II. Surface markers.";
RL   J. Natl. Cancer Inst. 64:477-483(1980).
//
RX   PubMed=6265077;
RA   Pizzo P.A., Chattopadhyay S.K., Magrath I.T., Del Giacco E.,
RA   Sherrick D., Gray T.E.;
RT   "Examination of Epstein-Barr virus and C-type proviral sequences in
RT   American and African lymphomas and derivative cell lines.";
RL   Cancer Res. 41:3165-3171(1981).
//
RX   PubMed=6286763; DOI=10.4049/jimmunol.129.3.1336;
RA   Benjamin D., Magrath I.T., Maguire R.T., Janus C., Todd-Kulikowsk H.D.,
RA   Parsons R.G.;
RT   "Immunoglobulin secretion by cell lines derived from African and
RT   American undifferentiated lymphomas of Burkitt's and non-Burkitt's
RT   type.";
RL   J. Immunol. 129:1336-1342(1982).
//
RX   PubMed=8176200; DOI=10.4049/jimmunol.152.10.4749;
RA   Benjamin D., Sharma V., Knobloch T.J., Armitage R.J., Dayton M.A.,
RA   Goodwin R.G.;
RT   "B cell IL-7. Human B cell lines constitutively secrete IL-7 and
RT   express IL-7 receptors.";
RL   J. Immunol. 152:4749-4757(1994).
//
RX   PubMed=8220424; DOI=10.1038/ng0993-56;
RA   Bhatia K.G., Huppi K., Spangler G., Siwarski D., Iyer R., Magrath I.T.;
RT   "Point mutations in the c-Myc transactivation domain are common in
RT   Burkitt's lymphoma and mouse plasmacytomas.";
RL   Nat. Genet. 5:56-61(1993).
//
RX   PubMed=8344493; DOI=10.1096/fasebj.7.10.8344493;
RA   Bhatia K.G., Goldschmidts W., Gutierrez M.I., Gaidano G., Dalla-Favera R.,
RA   Magrath I.T.;
RT   "Hemi- or homozygosity: a requirement for some but not other p53
RT   mutant proteins to accumulate and exert a pathogenetic effect.";
RL   FASEB J. 7:951-956(1993).
//
RX   PubMed=8568269; DOI=10.4049/jimmunol.156.4.1626;
RA   Benjamin D., Sharma V., Kubin M., Klein J.L., Sartori A., Holliday J.,
RA   Trinchieri G.;
RT   "IL-12 expression in AIDS-related lymphoma B cell lines.";
RL   J. Immunol. 156:1626-1637(1996).
//
RX   PubMed=9192833;
RA   Cherney B.W., Bhatia K.G., Sgadari C., Gutierrez M.I., Mostowski H.S.,
RA   Pike S.E., Gupta G., Magrath I.T., Tosato G.;
RT   "Role of the p53 tumor suppressor gene in the tumorigenicity of
RT   Burkitt's lymphoma cells.";
RL   Cancer Res. 57:2508-2515(1997).
//
RX   PubMed=9973220;
RA   Gutierrez M.I., Cherney B.W., Hussain A., Mostowski H.S., Tosato G.,
RA   Magrath I.T., Bhatia K.G.;
RT   "Bax is frequently compromised in Burkitt's lymphomas with
RT   irreversible resistance to Fas-induced apoptosis.";
RL   Cancer Res. 59:696-703(1999).
//
RX   PubMed=24590883; DOI=10.1002/gcc.22161;
RA   Murga Penas E.-M., Schilling G., Behrmann P., Klokow M.,
RA   Vettorazzi E., Bokemeyer C., Dierlamm J.;
RT   "Comprehensive cytogenetic and molecular cytogenetic analysis of 44
RT   Burkitt lymphoma cell lines: secondary chromosomal changes
RT   characterization, karyotypic evolution, and comparison with primary
RT   samples.";
RL   Genes Chromosomes Cancer 53:497-515(2014).
//