AC   CVCL_M596
DR   cancercelllines; CVCL_M596
DR   Wikidata; Q54890149
RX   PubMed=12097280;
CC   Problematic cell line: Parent cell line (HONE-1) seems to bear part of the HeLa genomic sequence and may be a derivative of HeLa and another cell of unknown origin.
CC   Characteristics: Partial revertant of the CPT30 camptothecin-resistant subline.
CC   Selected for resistance to: ChEBI; CHEBI:27656; Camptothecin (CPT).
CC   Sequence variation: Mutation; HGNC; 11986; TOP1; Simple; p.Glu418Lys (c.1252G>A); ClinVar=VCV000016774; Zygosity=Unspecified (PubMed=12097280).
DI   NCIt; C3871; Nasopharyngeal carcinoma
DI   ORDO; Orphanet_150; Nasopharyngeal carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_M595 ! HONE-1/CPT30
SX   Male
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 05-10-23; Version: 12
RX   PubMed=12097280;
RA   Chang J.-Y., Liu J.-F., Juang S.-H., Liu T.-W., Chen L.-T.;
RT   "Novel mutation of topoisomerase I in rendering cells resistant to
RT   camptothecin.";
RL   Cancer Res. 62:3716-3721(2002).