ID   MM-M1
AC   CVCL_M547
SY   MM.M1; MMM1
DR   Cosmic; 2081398
DR   Cosmic; 2302407
DR   Wikidata; Q54906021
RX   CelloPub=CLPUB00604;
RX   DOI=10.1007/0-306-46877-8_4;
RX   PubMed=1720489;
RX   PubMed=8695815;
RX   PubMed=8943038;
RX   PubMed=10936422;
RX   PubMed=17692805;
RX   PubMed=32123307;
WW   https://www.keatslab.org/myeloma-cell-lines/hmcl-characteristics
CC   Population: Japanese.
CC   Characteristics: Produces IgG kappa.
CC   Sequence variation: Gene fusion; HGNC; 1582; CCND1 + HGNC; 5477; IGH; Name(s)=IGH-CCND1 (PubMed=8695815).
CC   Omics: Array-based CGH.
CC   Omics: Transcriptome analysis by RNAseq.
DI   NCIt; C3242; Plasma cell myeloma
DI   ORDO; Orphanet_29073; Multiple myeloma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 21-03-23; Version: 13
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RX   CelloPub=CLPUB00604;
RA   Chow S.;
RT   "Targeted capture and sequencing of immunoglobulin rearrangements
RT   in multiple myeloma to enable detection of minimal residual disease.";
RL   Thesis MSc (2017), University of Toronto, Canada.
//
RX   DOI=10.1007/0-306-46877-8_4;
RA   Jernberg-Wiklund H., Nilsson K.;
RT   "Multiple myeloma cell lines.";
RL   (In) Human cell culture. Vol. 3. Cancer cell lines part 3; Masters J.R.W., Palsson B.O. (eds.); pp.81-155; Kluwer Academic Publishers; New York (2000).
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RX   PubMed=1720489; DOI=10.1016/0145-2126(91)90110-f;
RA   Suzuki A., Takahashi T., Okuno Y., Fukumoto M., Fukui H.,
RA   Koishihara Y., Ohsugi Y., Ohno Y., Imura H.;
RT   "Estimation of interleukin 6 production by reverse
RT   transcriptase-polymerase chain reaction in four human myeloma cell
RT   lines.";
RL   Leuk. Res. 15:1043-1050(1991).
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RX   PubMed=8695815; DOI=10.1182/blood.V88.2.674.bloodjournal882674;
RA   Chesi M., Bergsagel P.L., Brents L.A., Smith C.M., Gerhard D.S.,
RA   Kuehl W.M.;
RT   "Dysregulation of cyclin D1 by translocation into an IgH gamma switch
RT   region in two multiple myeloma cell lines.";
RL   Blood 88:674-681(1996).
//
RX   PubMed=8943038; DOI=10.1073/pnas.93.24.13931;
RA   Bergsagel P.L., Chesi M., Nardini E., Brents L.A., Kirby S.L.,
RA   Kuehl W.M.;
RT   "Promiscuous translocations into immunoglobulin heavy chain switch
RT   regions in multiple myeloma.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:13931-13936(1996).
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RX   PubMed=10936422; DOI=10.1016/S0145-2126(99)00195-2;
RA   Drexler H.G., Matsuo Y.;
RT   "Malignant hematopoietic cell lines: in vitro models for the study of
RT   multiple myeloma and plasma cell leukemia.";
RL   Leuk. Res. 24:681-703(2000).
//
RX   PubMed=17692805; DOI=10.1016/j.ccr.2007.07.003;
RA   Keats J.J., Fonseca R., Chesi M., Schop R., Baker A., Chng W.-J.,
RA   Van Wier S., Tiedemann R., Shi C.-X., Sebag M., Braggio E., Henry T.,
RA   Zhu Y.-X., Fogle H., Price-Troska T.L., Ahmann G.J., Mancini C.,
RA   Brents L.A., Kumar S.K., Greipp P., Dispenzieri A., Bryant B.,
RA   Mulligan G., Bruhn L., Barrett M.T., Valdez R., Trent J.M.,
RA   Stewart A.K., Carpten J.D., Bergsagel P.L.;
RT   "Promiscuous mutations activate the noncanonical NF-kappaB pathway in
RT   multiple myeloma.";
RL   Cancer Cell 12:131-144(2007).
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RX   PubMed=32123307; DOI=10.1038/s41375-020-0785-1;
RA   Sarin V., Yu K., Ferguson I.D., Gugliemini O., Nix M.A., Hann B.,
RA   Sirota M., Wiita A.P.;
RT   "Evaluating the efficacy of multiple myeloma cell lines as models for
RT   patient tumors via transcriptomic correlation analysis.";
RL   Leukemia 34:2754-2765(2020).
//