ID   MM-M1
AC   CVCL_M547
SY   MM.M1; MMM1
DR   Cosmic; 2081398
DR   Cosmic; 2302407
DR   Wikidata; Q54906021
RX   CelloPub=CLPUB00604;
RX   DOI=10.1007/0-306-46877-8_4;
RX   PubMed=1720489;
RX   PubMed=8695815;
RX   PubMed=8943038;
RX   PubMed=10936422;
RX   PubMed=17692805;
RX   PubMed=32123307;
WW   Info; Keats Lab; -; https://www.keatslab.org/myeloma-cell-lines
CC   Population: Japanese.
CC   Characteristics: Produces IgG kappa.
CC   Sequence variation: Gene fusion; HGNC; HGNC:1582; CCND1 + HGNC; HGNC:5477; IGH; Name(s)=IGH-CCND1 (PubMed=8695815).
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; Array-based CGH.
CC   Cell type: Plasma cell; CL=CL_0000786.
DI   NCIt; C3242; Plasma cell myeloma
DI   ORDO; Orphanet_29073; Multiple myeloma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 14-08-25; Version: 17
//
RX   PubMed=8695815; DOI=10.1182/blood.V88.2.674.bloodjournal882674;
RA   Chesi, Marta
RA   Bergsagel, Peter Leif
RA   Brents, Leslie A.
RA   Smith, Carissa M.
RA   Gerhard, Daniela S.
RA   Kuehl, Walter Michael
RT   "Dysregulation of cyclin D1 by translocation into an IgH gamma switch
RT   region in two multiple myeloma cell lines.";
RL   Blood 88:674-681(1996).
//
RX   PubMed=17692805; DOI=10.1016/j.ccr.2007.07.003; PMCID=PMC2083698;
RA   Keats, Jonathan J.
RA   Fonseca, Rafael
RA   Chesi, Marta
RA   Schop, Roelandt
RA   Baker, Angela
RA   Chng, Wee-Joo
RA   Van Wier, Scott
RA   Tiedemann, Rodger
RA   Shi, Chang-Xin
RA   Sebag, Michael
RA   Braggio, Esteban
RA   Henry, Travis
RA   Zhu, Yuan-Xiao
RA   Fogle, Homer
RA   Price-Troska, Tammy L.
RA   Ahmann, Gregory J.
RA   Mancini, Catherine
RA   Brents, Leslie A.
RA   Kumar, Shaji K.
RA   Greipp, Philip Robert
RA   Dispenzieri, Angela
RA   Bryant, Barb
RA   Mulligan, George
RA   Bruhn, Laurakay
RA   Barrett, Michael T.
RA   Valdez, Riccardo
RA   Trent, Jeffrey M.
RA   Stewart, A. Keith
RA   Carpten, John D.
RA   Bergsagel, Peter Leif
RT   "Promiscuous mutations activate the noncanonical NF-kappaB pathway in
RT   multiple myeloma.";
RL   Cancer Cell 12:131-144(2007).
//
RX   PubMed=1720489; DOI=10.1016/0145-2126(91)90110-f;
RA   Suzuki, Akira
RA   Takahashi, Takayuki
RA   Okuno, Yoshiaki
RA   Fukumoto, Manabu
RA   Fukui, Hiroyasu
RA   Koishihara, Yasuo
RA   Ohsugi, Yoshiaki
RA   Ohno, Yohichiro
RA   Imura, Hiroo
RT   "Estimation of interleukin 6 production by reverse
RT   transcriptase-polymerase chain reaction in four human myeloma cell
RT   lines.";
RL   Leuk. Res. 15:1043-1050(1991).
//
RX   PubMed=32123307; DOI=10.1038/s41375-020-0785-1; PMCID=PMC7483300;
RA   Sarin, Vishesh
RA   Yu, Katharine
RA   Ferguson, Ian D.
RA   Gugliemini, Olivia
RA   Nix, Matthew A.
RA   Hann, Byron
RA   Sirota, Marina
RA   Wiita, Arun P.
RT   "Evaluating the efficacy of multiple myeloma cell lines as models for
RT   patient tumors via transcriptomic correlation analysis.";
RL   Leukemia 34:2754-2765(2020).
//
RX   PubMed=10936422; DOI=10.1016/S0145-2126(99)00195-2;
RA   Drexler, Hans Gunther
RA   Matsuo, Yoshinobu
RT   "Malignant hematopoietic cell lines: in vitro models for the study of
RT   multiple myeloma and plasma cell leukemia.";
RL   Leuk. Res. 24:681-703(2000).
//
RX   DOI=10.1007/0-306-46877-8_4;
RA   Jernberg-Wiklund, Helena
RA   Nilsson, Kenneth
RT   "Multiple myeloma cell lines.";
RL   (In book chapter) Human cell culture. Vol. 3. Cancer cell lines part 3; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.81-155; Kluwer Academic Publishers; New York; USA (2000).
//
RX   CelloPub=CLPUB00604;
RA   Chow, Sharon
RT   "Targeted capture and sequencing of immunoglobulin rearrangements
RT   in multiple myeloma to enable detection of minimal residual disease.";
RL   Thesis MSc (2017); University of Toronto; Toronto; Canada.
//
RX   PubMed=8943038; DOI=10.1073/pnas.93.24.13931; PMCID=PMC19472;
RA   Bergsagel, Peter Leif
RA   Chesi, Marta
RA   Nardini, Elena
RA   Brents, Leslie A.
RA   Kirby, Suzanne Lee
RA   Kuehl, Walter Michael
RT   "Promiscuous translocations into immunoglobulin heavy chain switch
RT   regions in multiple myeloma.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:13931-13936(1996).
//