ID GIST48B AC CVCL_M441 SY GIST-48B DR cancercelllines; CVCL_M441 DR Cosmic; 2805390 DR GEO; GSM2527249 DR GEO; GSM2527262 DR GEO; GSM2527263 DR GEO; GSM2786736 DR Wikidata; Q54835859 RX PubMed=19706776; RX PubMed=25239608; RX PubMed=29866822; RX PubMed=30488756; CC Characteristics: Expresses KIT transcript and protein at essentially undetectable levels (PubMed=19706776). CC Sequence variation: Mutation; HGNC; HGNC:6342; KIT; Simple; p.Val560Asp (c.1679T>A); ClinVar=VCV000375914; Zygosity=Homozygous (PubMed=19706776). CC Sequence variation: Mutation; HGNC; HGNC:6342; KIT; Simple; p.Asp820Ala (c.2459A>C); ClinVar=VCV000953798; Zygosity=Heterozygous (PubMed=19706776). CC Omics: Genomics; ChIP-seq; H3K27ac. CC Omics: Genomics; Chromatin accessibility; ATAC-seq. CC Omics: Transcriptomics; RNAseq. CC Cell type: Interstitial cell of Cajal; CL=CL_0002088. DI NCIt; C3868; Gastrointestinal stromal tumor DI ORDO; Orphanet_44890; Gastrointestinal stromal tumor OX NCBI_TaxID=9606; ! Homo sapiens (Human) HI CVCL_7041 ! GIST48 CA Cancer cell line DT Created: 05-11-13; Last updated: 10-04-25; Version: 15 // RX PubMed=19706776; DOI=10.1158/0008-5472.CAN-08-4004; PMCID=PMC2905726; RA Muhlenberg T., Zhang Y.-X., Wagner A.J., Grabellus F., Bradner J.E., RA Taeger G., Lang H., Taguchi T., Schuler M., Fletcher J.A., Bauer S.; RT "Inhibitors of deacetylases suppress oncogenic KIT signaling, RT acetylate HSP90, and induce apoptosis in gastrointestinal stromal RT tumors."; RL Cancer Res. 69:6941-6950(2009). // RX PubMed=25239608; DOI=10.1158/1078-0432.CCR-14-1397; PMCID=PMC4233175; RA Garner A.P., Gozgit J.M., Anjum R., Vodala S., Schrock A.B., Zhou T.-J., RA Serrano C., Eilers G., Zhu M.-J., Ketzer J., Wardwell S., Ning Y., RA Song Y., Kohlmann A., Wang F., Clackson T., Heinrich M.C., RA Fletcher J.A., Bauer S., Rivera V.M.; RT "Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and RT shows therapeutic potential in heavily pretreated gastrointestinal RT stromal tumor (GIST) patients."; RL Clin. Cancer Res. 20:5745-5755(2014). // RX PubMed=29866822; DOI=10.1073/pnas.1802079115; PMCID=PMC6016782; RA Hemming M.L., Lawlor M.A., Zeid R., Lesluyes T., Fletcher J.A., RA Raut C.P., Sicinska E.T., Chibon F., Armstrong S.A., Demetri G.D., RA Bradner J.E.; RT "Gastrointestinal stromal tumor enhancers support a transcription RT factor network predictive of clinical outcome."; RL Proc. Natl. Acad. Sci. U.S.A. 115:E5746-E5755(2018). // RX PubMed=30488756; DOI=10.1080/15384101.2018.1553335; PMCID=PMC6300111; RA Tu Y.-Q., Zuo R., Ni N., Eilers G., Wu D.-L., Pei Y.-T., Nie Z.-M., RA Wu Y.-Q., Wu Y.-H., Ou W.-B.; RT "Activated tyrosine kinases in gastrointestinal stromal tumor with RT loss of KIT oncoprotein expression."; RL Cell Cycle 17:2577-2592(2018). //