ID   KB-ChR-8-5-11-24
AC   CVCL_M125
SY   KB-ChR-24; KB-8-5-11-24; KB-C1; KBC-1
DR   Wikidata; Q54899554
RX   PubMed=2897240;
RX   PubMed=3711108;
RX   PubMed=3856953;
CC   Problematic cell line: Contaminated. Ancestral cell line (KB) has been shown to be a HeLa derivative.
CC   Population: African American.
CC   Selected for resistance to: ChEBI; CHEBI_23359; Colchicine.
CC   Sequence variation: Mutation; HGNC; HGNC:40; ABCB1; Simple; p.Gly185Val (c.554_555GA>TT); Zygosity=Unspecified (PubMed=2897240).
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Transformant: ChEBI; CHEBI_23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
DI   NCIt; C27677; Human papillomavirus-related endocervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_5997 ! KB-ChR-8-5-11
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 06-05-13; Last updated: 14-08-25; Version: 19
CH   CVCL_1D83 ! KB-C1-R1
CH   CVCL_1D80 ! KB-C1.5
//
RX   PubMed=3711108; DOI=10.1016/S0021-9258(19)57466-X;
RA   Shen, Ding-Wu
RA   Cardarelli, Carol O.
RA   Hwang, Jaulang
RA   Cornwell, Marilyn
RA   Richert, Nancy
RA   Ishii, Shunsuke
RA   Pastan, Ira
RA   Gottesman, Michael Marc
RT   "Multiple drug-resistant human KB carcinoma cells independently
RT   selected for high-level resistance to colchicine, adriamycin, or
RT   vinblastine show changes in expression of specific proteins.";
RL   J. Biol. Chem. 261:7762-7770(1986).
//
RX   PubMed=3856953; DOI=10.1007/BF01534700;
RA   Akiyama, Shin-ichi
RA   Fojo, Antonio
RA   Hanover, John A.
RA   Pastan, Ira
RA   Gottesman, Michael Marc
RT   "Isolation and genetic characterization of human KB cell lines
RT   resistant to multiple drugs.";
RL   Somat. Cell Mol. Genet. 11:117-126(1985).
//
RX   PubMed=2897240; DOI=10.1016/0092-8674(88)90568-5;
RA   Choi, Kyunghee
RA   Chen, Chang-Jie
RA   Kriegler, Michael
RA   Roninson, Igor B.
RT   "An altered pattern of cross-resistance in multidrug-resistant human
RT   cells results from spontaneous mutations in the mdr1 (P-glycoprotein)
RT   gene.";
RL   Cell 53:519-529(1988).
//