AC   CVCL_M098
SY   MLOY4; Murine Long bone Osteocyte-Y4
DR   BTO; BTO:0005489
DR   EFO; EFO_0005394
DR   GEO; GSM1520095
DR   GEO; GSM1520096
DR   GEO; GSM1520097
DR   GEO; GSM1520098
DR   GEO; GSM1520099
DR   GEO; GSM1520100
DR   GEO; GSM1520101
DR   GEO; GSM1520102
DR   GEO; GSM1520103
DR   GEO; GSM1520104
DR   GEO; GSM1520105
DR   GEO; GSM1520106
DR   Kerafast; EKC002
DR   Lonza; 166
DR   Ubigene; YC-C037
DR   Wikidata; Q54905979
RX   CelloPub=CLPUB00625;
RX   Patent=US6358737;
RX   PubMed=9421234;
RX   PubMed=10084404;
RX   PubMed=12412815;
RX   PubMed=16738320;
RX   PubMed=22130923;
CC   Group: Patented cell line.
CC   Group: Space-flown cell line (cellonaut).
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-12161.
CC   Characteristics: Useful to study effects of fluid flow and substrate stretching on activation of osteocyte-specific signaling pathways (Kerafast=EKC002).
CC   Doubling time: 15.8 hours (CelloPub=CLPUB00625).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Bone, long bone; UBERON=UBERON_0002495.
CC   Cell type: Osteocyte; CL=CL_0000137.
CC   Breed/subspecies: (C57BL/6J x BALB/cJ) F2 Bgla promoter T-Ag transgenic.
ST   Source(s): Ubigene
ST   Mouse STR 12-1: 17
ST   Mouse STR 15-3: 22.3
ST   Mouse STR 18-3: 17,18
ST   Mouse STR 4-2: 20.3,21.3
ST   Mouse STR 5-5: 14
ST   Mouse STR 6-4: 18
ST   Mouse STR 6-7: 17
ST   Mouse STR X-1: 25
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
SX   Sex unspecified
AG   14D
CA   Transformed cell line
DT   Created: 06-05-13; Last updated: 05-10-23; Version: 21
RX   CelloPub=CLPUB00625;
RA   Lau P., Hellweg C.E., Kirchner S., Arenz A., Baumstark-Khan C.,
RA   Horneck G.;
RT   "Induction of DNA-strand breaks after X-irradiation in murine bone
RT   cells of various differentiation capacities.";
RL   (In) Proceedings of 35th COSPAR Scientific Assembly; pp.1960-1960; Paris (2004).
RX   Patent=US6358737;
RA   Bonewald L.F., Kato Y.;
RT   "Osteocyte cell lines.";
RL   Patent number US6358737, 19-Mar-2002.
RX   PubMed=9421234; DOI=10.1359/jbmr.1997.12.12.2014;
RA   Kato Y., Windle J.J., Koop B.A., Mundy G.R., Bonewald L.F.;
RT   "Establishment of an osteocyte-like cell line, MLO-Y4.";
RL   J. Bone Miner. Res. 12:2014-2023(1997).
RX   PubMed=10084404; DOI=10.1007/s007740050066;
RA   Bonewald L.F.;
RT   "Establishment and characterization of an osteocyte-like cell line,
RT   MLO-Y4.";
RL   J. Bone Miner. Metab. 17:61-65(1999).
RX   PubMed=12412815; DOI=10.1359/jbmr.2002.17.11.2068;
RA   Zhao S., Zhang Y.K., Harris S., Ahuja S.S., Bonewald L.F.;
RT   "MLO-Y4 osteocyte-like cells support osteoclast formation and
RT   activation.";
RL   J. Bone Miner. Res. 17:2068-2079(2002).
RX   PubMed=16738320; DOI=10.1128/mcb.02120-05;
RA   Zhang K.-Q., Barragan-Adjemian C., Ye L., Kotha S., Dallas M.,
RA   Lu Y.-B., Zhao S.-J., Harris M., Harris S.E., Feng J.Q., Bonewald L.F.;
RT   "E11/gp38 selective expression in osteocytes: regulation by mechanical
RT   strain and role in dendrite elongation.";
RL   Mol. Cell. Biol. 26:4539-4552(2006).
RX   PubMed=22130923; DOI=10.1007/978-1-61779-415-5_6;
RA   Rosser J., Bonewald L.F.;
RT   "Studying osteocyte function using the cell lines MLO-Y4 and MLO-A5.";
RL   Methods Mol. Biol. 816:67-81(2012).