ID   EJ-30 clone B3
AC   CVCL_LN36
SY   B3
DR   cancercelllines; CVCL_LN36
DR   Wikidata; Q54832172
RX   PubMed=11228547;
RX   PubMed=12827497;
CC   Problematic cell line: Contaminated. Grand-parent cell line (Ej138) has been shown to be a T24 derivative.
CC   Population: Caucasian; Swedish.
CC   Sequence variation: Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012600; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr126Ter (c.378C>G); ClinVar=VCV000578988; Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; Q9QNF7; Human herpesvirus 1 TK.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
CC   Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
DI   NCIt; C4912; Bladder carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_LN34 ! EJ-30
SX   Female
AG   82Y
CA   Cancer cell line
DT   Created: 15-11-17; Last updated: 14-08-25; Version: 15
CH   CVCL_LN37 ! EJ-30 clone B3-WrnDN1
//
RX   PubMed=11228547; DOI=10.1038/sj.neo.7900107; PMCID=PMC1508089;
RA   Fouladi, Bijan
RA   Sabatier, Laure
RA   Miller, Douglas
RA   Pottier, Geraldine
RA   Murnane, John Patrick
RT   "The relationship between spontaneous telomere loss and chromosome
RT   instability in a human tumor cell line.";
RL   Neoplasia 2:540-554(2000).
//
RX   PubMed=12827497; DOI=10.1007/s00439-003-0972-y;
RA   Bai, Yun
RA   Murnane, John Patrick
RT   "Telomere instability in a human tumor cell line expressing a
RT   dominant-negative WRN protein.";
RL   Hum. Genet. 113:337-347(2003).
//