ID   DX3-LT5.1
AC   CVCL_LI22
SY   DX3.LT5.1; DX3 LT5.1; DX3LT5.1; DX3-azaC-LT5.1; LT5.1
DR   Wikidata; Q54831608
RX   PubMed=2060182;
RX   PubMed=2416434;
RX   PubMed=7780963;
CC   Characteristics: Highly metastatic in mice.
CC   Selected for resistance to: ChEBI; CHEBI_2038; 5-azacytidine (5-azaC).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (from parent cell line).
CC   Omics: Proteomics; 2DE.
CC   Derived from site: Metastatic; Hypodermis; UBERON=UBERON_0002072.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_5650 ! SK-MEL-93 DX-3
SX   Female
AG   71Y
CA   Cancer cell line
DT   Created: 15-11-17; Last updated: 10-04-25; Version: 8
//
RX   PubMed=2060182; DOI=10.1007/BF01753726;
RA   Easty D.J., Hart I.R., Patel K., Seymour C., Yacoub M.H., Domscheit A.,
RA   Gunther S., Postel W., Gorg A., Dunn M.J.;
RT   "Changes in protein expression during melanoma differentiation
RT   determined by computer analysis of 2-D gels.";
RL   Clin. Exp. Metastasis 9:221-230(1991).
//
RX   PubMed=2416434;
RA   Ormerod E.J., Everett C.A., Hart I.R.;
RT   "Enhanced experimental metastatic capacity of a human tumor line
RT   following treatment with 5-azacytidine.";
RL   Cancer Res. 46:884-890(1986).
//
RX   PubMed=7780963;
RA   Easty D.J., Guthrie B.A., Maung K., Farr C.J., Lindberg R.A.,
RA   Toso R.J., Herlyn M., Bennett D.C.;
RT   "Protein B61 as a new growth factor: expression of B61 and
RT   up-regulation of its receptor epithelial cell kinase during melanoma
RT   progression.";
RL   Cancer Res. 55:2528-2532(1995).
//