ID   NB-SD
AC   CVCL_LF68
SY   NBSD
DR   cancercelllines; CVCL_LF68
DR   Cosmic; 1161998
DR   GEO; GSM2371247
DR   GEO; GSM2394380
DR   IARC_TP53; 24984
DR   Wikidata; Q54907508
RX   PubMed=9802058;
RX   PubMed=9815701;
RX   PubMed=18724359;
RX   PubMed=28350380;
CC   Sequence variation: Mutation; HGNC; HGNC:427; ALK; Simple; p.Phe1174Leu (c.3522C>A); ClinVar=VCV000217852; Zygosity=Unspecified (PubMed=18724359; PubMed=28350380).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys176Phe (c.527G>T); ClinVar=VCV000376569; Zygosity=Homozygous (PubMed=9802058).
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C3270; Neuroblastoma
DI   ORDO; Orphanet_635; Neuroblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   1-3Y
CA   Cancer cell line
DT   Created: 22-08-17; Last updated: 10-04-25; Version: 12
//
RX   PubMed=9802058;
RA   McPake C.R., Tillman D.M., Poquette C.A., George E.O., Houghton J.A.,
RA   Harris L.C.;
RT   "Bax is an important determinant of chemosensitivity in pediatric
RT   tumor cell lines independent of Bcl-2 expression and p53 status.";
RL   Oncol. Res. 10:235-244(1998).
//
RX   PubMed=9815701;
RA   Thompson J., Zamboni W.C., Cheshire P.J., Lutz L., Luo X.-L., Li Y.-L.,
RA   Houghton J.A., Stewart C.F., Houghton P.J.;
RT   "Efficacy of systemic administration of irinotecan against
RT   neuroblastoma xenografts.";
RL   Clin. Cancer Res. 3:423-431(1997).
//
RX   PubMed=18724359; DOI=10.1038/nature07261; PMCID=PMC2672043;
RA   Mosse Y.P., Laudenslager M., Longo L., Cole K.A., Wood A.,
RA   Attiyeh E.F., Laquaglia M.J., Sennett R., Lynch J.E., Perri P.,
RA   Laureys G., Speleman F., Kim C., Hou C.-P., Hakonarson H., Torkamani A.,
RA   Schork N.J., Brodeur G.M., Tonini G.P., Rappaport E., Devoto M.,
RA   Maris J.M.;
RT   "Identification of ALK as a major familial neuroblastoma
RT   predisposition gene.";
RL   Nature 455:930-935(2008).
//
RX   PubMed=28350380; DOI=10.1038/sdata.2017.33; PMCID=PMC5369315;
RA   Harenza J.L., Diamond M.A., Adams R.N., Song M.M., Davidson H.L.,
RA   Hart L.S., Dent M.H., Fortina P., Reynolds C.P., Maris J.M.;
RT   "Transcriptomic profiling of 39 commonly-used neuroblastoma cell
RT   lines.";
RL   Sci. Data 4:170033.1-170033.8(2017).
//