ID   C5065
SY   DFT1.C5065
DR   Wikidata; Q54808194
RX   PubMed=23479617;
RX   PubMed=25708088;
RX   PubMed=27936237;
RX   PubMed=32937435;
CC   Group: Marsupial cell line.
CC   Characteristics: Originates from DFT1 strain 3.
DI   NCIt; C176223; Devil facial tumor disease 1
OX   NCBI_TaxID=9305; ! Sarcophilus harrisii (Tasmanian devil)
OI   CVCL_LB75 ! 1/2Pea
OI   CVCL_LB76 ! 1426
OI   CVCL_LB77 ! 2112
OI   CVCL_LB78 ! 4906
SX   Female
CA   Cancer cell line
DT   Created: 22-08-17; Last updated: 21-03-23; Version: 4
RX   PubMed=23479617; DOI=10.1073/pnas.1219920110;
RA   Siddle H.V.T., Kreiss A., Tovar C., Yuen C.K., Cheng Y., Belov K.,
RA   Swift K., Pearse A.-M., Hamede R., Jones M.E., Skjodt K., Woods G.M.,
RA   Kaufman J.;
RT   "Reversible epigenetic down-regulation of MHC molecules by devil
RT   facial tumour disease illustrates immune escape by a contagious
RT   cancer.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:5103-5108(2013).
RX   PubMed=25708088; DOI=10.1016/j.vaccine.2015.01.039;
RA   Kreiss A., Brown G.K., Tovar C., Lyons A.B., Woods G.M.;
RT   "Evidence for induction of humoral and cytotoxic immune responses
RT   against devil facial tumor disease cells in Tasmanian devils
RT   (Sarcophilus harrisii) immunized with killed cell preparations.";
RL   Vaccine 33:3016-3025(2015).
RX   PubMed=27936237; DOI=10.1371/journal.pone.0168068;
RA   Patchett A.L., Darby J.M., Tovar C., Lyons A.B., Woods G.M.;
RT   "The immunomodulatory small molecule imiquimod induces apoptosis in
RT   devil facial tumour cell lines.";
RL   PLoS ONE 11:E0168068-E0168068(2016).
RX   PubMed=32937435; DOI=10.1126/sciadv.aba5031;
RA   Flies A.S., Darby J.M., Lennard P.R., Murphy P.R., Ong C.E.B.,
RA   Pinfold T.L., De Luca A., Lyons A.B., Woods G.M., Patchett A.L.;
RT   "A novel system to map protein interactions reveals evolutionarily
RT   conserved immune evasion pathways on transmissible cancers.";
RL   Sci. Adv. 6:eaba5031.1-eaba5031.13(2020).