ID   1E8 [Human leukemia]
AC   CVCL_L811
DR   BioSample; SAMN06481104
DR   cancercelllines; CVCL_L811
DR   Wikidata; Q54582833
RX   PubMed=7528218;
RX   PubMed=20143388;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Parent cell line (BLIN-1) has been shown to be a NALM-6 derivative (PubMed=20143388).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00169.
CC   Population: Caucasian.
CC   Sequence variation: Gene fusion; HGNC; HGNC:50800; DUX4 + HGNC; HGNC:5477; IGH; Name(s)=IGH-DUX4; Note=The translocation occurs in the silenced IGH allele (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Arg1068Ter (c.3202C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Ala146Thr (c.436G>A); ClinVar=VCV002900866; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9864; RARA; Simple; p.Gln45Ter (c.133C>T); ClinVar=VCV000393019; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9143; Adult B acute lymphoblastic leukemia
DI   ORDO; Orphanet_99860; Precursor B-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_8173 ! BLIN-1
SX   Male
AG   19Y
CA   Cancer cell line
DT   Created: 06-05-13; Last updated: 27-11-25; Version: 29
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RX   PubMed=7528218; DOI=10.1016/S0021-9258(18)31664-8;
RA   Weng, Wen-Kai
RA   Jarvis, Lisa
RA   LeBien, Tucker W.
RT   "Signaling through CD19 activates Vav/mitogen-activated protein kinase
RT   pathway and induces formation of a CD19/Vav/phosphatidylinositol
RT   3-kinase complex in human B cell precursors.";
RL   J. Biol. Chem. 269:32514-32521(1994).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis, Amanda
RA   Theodosopoulos, George
RA   Atkin, Isobel
RA   Drexler, Hans Gunther
RA   Kohara, Arihiro
RA   MacLeod, Roderick A.F.
RA   Masters, John R.W.
RA   Nakamura, Yukio
RA   Reid, Yvonne A.
RA   Reddel, Roger Robert
RA   Freshney, Robert Ian
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//