ID   AG05397
AC   CVCL_L780
SY   AG5397
DR   CLO; CLO_0035217
DR   Coriell; AG05397
DR   Wikidata; Q54739981
RX   CelloPub=CLPUB00597;
RX   PubMed=17668376;
RX   PubMed=18691744;
RX   PubMed=23716668;
RX   PubMed=24119401;
CC   Population: Caucasian.
CC   Derived from site: In situ; Chest, skin; UBERON=UBERON_0001868.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
DI   NCIt; C2993; Down syndrome
DI   ORDO; Orphanet_870; Down syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   1Y
CA   Finite cell line
DT   Created: 06-05-13; Last updated: 29-06-23; Version: 17
CH   CVCL_D012 ! DS1-iPS4
CH   CVCL_EJ81 ! WISCi005-A
CH   CVCL_EJ83 ! WISCi005-B
CH   CVCL_EJ82 ! WISCi005-C
//
RX   PubMed=23716668; DOI=10.1073/pnas.1216575110; PMCID=PMC3683748;
RA   Weick, Jason P.
RA   Held, Dustie L.
RA   Bonadurer, George Fred 3rd
RA   Doers, Matthew E.
RA   Liu, Yan
RA   Maguire, Chelsie
RA   Clark, Aaron
RA   Knackert, Joshua A.
RA   Molinarolo, Katharine
RA   Musser, Michael T.
RA   Yao, Lin
RA   Yin, Ying-Nan
RA   Lu, Jian-Feng
RA   Zhang, Xiao-Qing
RA   Zhang, Su-Chun
RA   Bhattacharyya, Anita
RT   "Deficits in human trisomy 21 iPSCs and neurons.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:9962-9967(2013).
//
RX   PubMed=18691744; DOI=10.1016/j.cell.2008.07.041; PMCID=PMC2633781;
RA   Park, In-Hyun
RA   Arora, Natasha
RA   Huo, Hong-Guang
RA   Maherali, Nimet
RA   Ahfeldt, Tim
RA   Shimamura, Akiko
RA   Lensch, M. William
RA   Cowan, Chad A.
RA   Hochedlinger, Konrad
RA   Daley, George Quentin
RT   "Disease-specific induced pluripotent stem cells.";
RL   Cell 134:877-886(2008).
//
RX   PubMed=24119401; DOI=10.1016/j.molcel.2013.09.009; PMCID=PMC4039290;
RA   Chen, Jia-Yun
RA   Lin, Jia-Ren
RA   Tsai, Feng-Chiao
RA   Meyer, Tobias
RT   "Dosage of Dyrk1a shifts cells within a p21-cyclin D1 signaling map to
RT   control the decision to enter the cell cycle.";
RL   Mol. Cell 52:87-100(2013).
//
RX   CelloPub=CLPUB00597;
RG   National Institute on Aging;
RT   "1994 catalog of cell lines. NIA Aging Cell Repository.";
RL   (In misc. document) Institute for Medical Research (Camden, N.J.); pp.1-351; National Institutes of Health; Bethesda; USA (1994).
//
RX   PubMed=17668376; DOI=10.1086/519248; PMCID=PMC1950802;
RA   Prandini, Paola
RA   Deutsch, Samuel
RA   Lyle, Robert
RA   Gagnebin, Maryline
RA   Delucinge-Vivier, Celine
RA   Delorenzi, Mauro
RA   Gehrig, Corinne
RA   Descombes, Patrick
RA   Sherman, Stephanie L.
RA   Dagna-Bricarelli, Franca
RA   Baldo, Chiara
RA   Novelli, Antonio
RA   Dallapiccola, Bruno
RA   Antonarakis, Stylianos E.
RT   "Natural gene-expression variation in Down syndrome modulates the
RT   outcome of gene-dosage imbalance.";
RL   Am. J. Hum. Genet. 81:252-263(2007).
//