ID   Vogel
AC   CVCL_L422
DR   GEO; GSM1974800
DR   Wikidata; Q54993305
RX   PubMed=21908323;
RX   PubMed=22916246;
RX   PubMed=27197945;
RX   PubMed=31175136;
CC   Part of: FACC canine tumor cell line panel.
CC   Doubling time: 35.9 hours (PubMed=22916246).
CC   Sequence variation: Mutation; VGNC; 38514; BRAF; Simple; p.Val588Glu (c.1763T>A); Zygosity=Heterozygous (PubMed=27197945; PubMed=31175136).
CC   Sequence variation: Mutation; VGNC; 43120; MED12; Simple; p.Leu1349fs (c.4041_4044dupTATT); Zygosity=Heterozygous (PubMed=31175136).
CC   Sequence variation: Mutation; VGNC; 47719; TP53; Simple; p.Val162Leu (c.484G>T); Zygosity=Heterozygous (PubMed=31175136).
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Bone; UBERON=UBERON_0002481.
ST   Source(s): PubMed=27197945; PubMed=31175136
ST   Dog FHC2010: 235,239
ST   Dog FHC2054: 156,172
ST   Dog FHC2079: 271,275
ST   Dog PEZ1: 115,119
ST   Dog PEZ3: 115,131
ST   Dog PEZ5: 103
ST   Dog PEZ6: 176,183
ST   Dog PEZ8: 228,232
ST   Dog PEZ12: 274
ST   Dog PEZ20: 176
DI   NCIt; C120045; Canine osteosarcoma
OX   NCBI_TaxID=9615; ! Canis lupus familiaris (Dog)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 06-05-13; Last updated: 29-06-23; Version: 15
//
RX   PubMed=21908323; DOI=10.1177/1040638711408064;
RA   O'Donoghue L.E., Rivest J.P., Duval D.L.;
RT   "Polymerase chain reaction-based species verification and
RT   microsatellite analysis for canine cell line validation.";
RL   J. Vet. Diagn. Invest. 23:780-785(2011).
//
RX   PubMed=22916246; DOI=10.1371/journal.pone.0043355;
RA   Maeda J., Yurkon C.R., Fujisawa H., Kaneko M., Genet S.C.,
RA   Roybal E.J., Rota G.W., Saffer E.R., Rose B.J., Hanneman W.H.,
RA   Thamm D.H., Kato T.A.;
RT   "Genomic instability and telomere fusion of canine osteosarcoma
RT   cells.";
RL   PLoS ONE 7:E43355-E43355(2012).
//
RX   PubMed=27197945; DOI=10.1111/vco.12192;
RA   Fowles J.S., Dailey D.D., Gustafson D.L., Thamm D.H., Duval D.L.;
RT   "The Flint Animal Cancer Center (FACC) canine tumour cell line panel:
RT   a resource for veterinary drug discovery, comparative oncology and
RT   translational medicine.";
RL   Vet. Comp. Oncol. 15:481-492(2017).
//
RX   PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346;
RA   Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.;
RT   "Identifying candidate druggable targets in canine cancer cell lines
RT   using whole exome sequencing.";
RL   Mol. Cancer Ther. 18:1460-1471(2019).
//