ID   COS31
AC   CVCL_L346
SY   COS 31; Canine osteosarcoma cells from passage 31
DR   BTO; BTO_0005363
DR   Wikidata; Q54814327
RX   PubMed=9827351;
RX   PubMed=9827352;
RX   PubMed=33446089;
CC   Doubling time: 28 hours (PubMed=9827352).
CC   Omics: Transcriptomics; RNAseq; Single cell.
CC   Derived from site: Metastatic; Bone, left distal radius; UBERON=UBERON_0004407.
CC   Breed/subspecies: Saint Bernard; VBO=VBO_0201160.
DI   NCIt; C120045; Canine osteosarcoma
OX   NCBI_TaxID=9615; ! Canis lupus familiaris (Dog)
SX   Male
AG   6Y
CA   Cancer cell line
DT   Created: 06-05-13; Last updated: 10-04-25; Version: 14
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RX   PubMed=9827351;
RA   Shoieb A.M., Hahn K.A., Van Laack R.L., Barnhill M.A.;
RT   "In vitro reversal of glutathione-S-transferase-mediated resistance in
RT   canine osteosarcoma (COS31) cells.";
RL   In Vivo 12:455-462(1998).
//
RX   PubMed=9827352;
RA   Shoieb A.M., Hahn K.A., Barnhill M.A.;
RT   "An in vivo/in vitro experimental model system for the study of human
RT   osteosarcoma: canine osteosarcoma cells (COS31) which retain
RT   osteoblastic and metastatic properties in nude mice.";
RL   In Vivo 12:463-472(1998).
//
RX   PubMed=33446089; DOI=10.1177/1040638720985242; PMCID=PMC7944434;
RA   Ayers J., Milner R.J., Cortes-Hinojosa G., Riva A., Axiak-Bechtel S.M.,
RA   Sahay B., Cascio M., Lejeune A., Shiomitsu K., Souza C., Hernandez O.,
RA   Salute M.E.;
RT   "Novel application of single-cell next-generation sequencing for
RT   determination of intratumoral heterogeneity of canine osteosarcoma
RT   cell lines.";
RL   J. Vet. Diagn. Invest. 33:261-278(2021).
//