ID   PathHunter U2OS AHR Protein Interaction
AC   CVCL_KZ74
DR   DiscoverX; 93-1113C3
DR   Wikidata; Q54938069
CC   Population: Caucasian.
CC   Characteristics: PathHunter NHR protein interaction cell lines co-express a NHR tagged with a beta-galactosidase fragment (ProLink=PK) and a receptor co-activator tagged with another fragment (Enzyme Acceptor=EA). Activation of the NHR results in co-activator-EA recruitment thus resulting into a catalytically active enzyme that generate a chemiluminescent signal.
CC   Sequence variation: Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:348; AHR.
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:700; ARNT (Note=With p.Met1_Lys155del and p.Ser271_Glu789del).
CC   Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
DI   NCIt; C9145; Osteosarcoma
DI   ORDO; Orphanet_668; Osteosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0042 ! U2OS
SX   Female
AG   15Y
CA   Cancer cell line
DT   Created: 22-08-17; Last updated: 19-12-24; Version: 10
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