ID   PathHunter CHO-K1 SSTR2 Activated GPCR Internalization
AC   CVCL_KZ11
SY   PathHunter SSTR2 Activated GPCR Internalization CHO-K1
DR   DiscoverX; 93-0676C2
DR   Wikidata; Q54937980
CC   Characteristics: PathHunter activated GPCR internalization cell lines co-express an untagged GPCR, a beta-arrestin tagged with a beta-galactosidase fragment (Enzyme Acceptor=EA) and a second beta-galactosidase fragment (ProLink=PK) localized to the endosomes. Beta-arrestin recruitment is followed by internalization of the GPCR/arrestin-EA complex in PK-tagged endosomes and allowing complementation of the PK and EA enzyme fragments thus resulting into a catalytically active enzyme that generate a chemiluminescent signal.
CC   Transfected with: HGNC; 11331; SSTR2.
CC   Transfected with: HGNC; 712; ARRB2.
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_0214 ! CHO-K1
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 22-08-17; Last updated: 30-01-24; Version: 7
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