ID   InCELL Hunter U2OS BCL2L1-BAX Protein Binding
AC   CVCL_KW13
SY   InCELL Hunter U2OS Bcl2L1-Bax
DR   DiscoverX; 96-0009C3
DR   Wikidata; Q54897728
CC   Population: Caucasian.
CC   Characteristics: InCELL Hunter cell lines express a transfected target protein fragment tagged with a beta-galactosidase fragment (enhanced ProLabel=ePL). The technology measures compound binding to an intracellular target by detecting changes in protein stability. The amount of fusion is quantified through the addition of substrate and a second enzyme fragment (Enzyme acceptor=EA).
CC   Sequence variation: Mutation; HGNC; HGNC:9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:959; BAX (Note=With p.Met1_Pro51del and p.Asn73_Gly192del).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:992; BCL2L1.
CC   Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
DI   NCIt; C9145; Osteosarcoma
DI   ORDO; Orphanet_668; Osteosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0042 ! U2OS
SX   Female
AG   15Y
CA   Cancer cell line
DT   Created: 22-08-17; Last updated: 10-04-25; Version: 11
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