ID   CellSensor AP1-bla A375
AC   CVCL_KS59
SY   CellSensor AP-1-bla A375; AP1-bla A375; AP-1-bla A375
DR   cancercelllines; CVCL_KS59
DR   Wikidata; Q54809148
WW   https://www.thermofisher.com/order/catalog/product/K1660
CC   Population: Caucasian.
CC   Characteristics: Transfected with a plasmid containing a beta-lactamase reporter gene under the control of the AP1 response element.
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Transfected with: UniProtKB; P62593; Escherichia coli beta-lactamase bla (with p.Met1_Phe22del, p.Ala23Met, p.Val82Ile and p.Met184Val).
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
DI   NCIt; C3802; Amelanotic melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0132 ! A-375
SX   Female
AG   54Y
CA   Cancer cell line
DT   Created: 22-08-17; Last updated: 05-10-23; Version: 14
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