ID   CellSensor Gli-bla 22Rv1
AC   CVCL_KS53
SY   CellSensor Gli-bla 22Rv.1; Gli-bla 22Rv1; Gli-bla 22Rv.1
DR   cancercelllines; CVCL_KS53
DR   Wikidata; Q54809181
WW   Provider; Thermo Fisher; K1838; https://www.thermofisher.com/order/catalog/product/K1838
CC   Population: Caucasian.
CC   Characteristics: Transfected with a plasmid containing a beta-lactamase reporter gene under control of the Gli response element.
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Leu597Arg (c.1790T>G); ClinVar=VCV000013968; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7133; KMT2D; Simple; p.Arg1252Ter (c.3754C>T); ClinVar=VCV000167228; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7133; KMT2D; Simple; p.Gln3158Ter (c.9472C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Gln546Arg (c.1637A>G); ClinVar=VCV000045466; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln331Arg (c.992A>G); ClinVar=VCV000421319; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P33967; B.cereus Bsr.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P62593; Escherichia coli beta-lactamase bla (Note=With p.Met1_Phe22del, p.Ala23Met, p.Val82Ile and p.Met184Val).
CC   Derived from site: In situ; Prostate; UBERON=UBERON_0002367.
DI   NCIt; C4863; Prostate carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1045 ! 22Rv1
SX   Male
AG   Adult
CA   Cancer cell line
DT   Created: 22-08-17; Last updated: 10-04-25; Version: 15
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