ID   K562/NFAT-luc
AC   CVCL_KS44
DR   Wikidata; Q54899415
RX   PubMed=16834536;
CC   Population: Caucasian.
CC   Characteristics: The luciferase reporter gene is under the control of multiple copies of the NFAT response element (PubMed=16834536).
CC   Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln136fs*13 (c.406_407insC); Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P08659; Firefly luciferase.
CC   Discontinued: Thermo Fisher/Panomics; Catalog number RC0009.
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C9110; Blast phase chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0004 ! K-562
SX   Female
AG   53Y
CA   Cancer cell line
DT   Created: 22-08-17; Last updated: 10-04-25; Version: 18
//
RX   PubMed=16834536; DOI=10.1089/adt.2006.4.307;
RA   Lai C.-F., Jiang X., Li X.-Q.;
RT   "Development of luciferase reporter-based cell assays.";
RL   Assay Drug Dev. Technol. 4:307-315(2006).
//