ID   MCF-7/AdVp3000
AC   CVCL_KS20
SY   MCF-7 AdVp3000; MCF AdVp3000
DR   cancercelllines; CVCL_KS20
DR   Wikidata; Q54904352
RX   PubMed=9178101;
RX   PubMed=9892175;
RX   PubMed=11406094;
RX   PubMed=11559526;
RX   PubMed=12116365;
RX   PubMed=15901850;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:74; ABCG2; Simple; p.Arg482Thr (c.1445G>C); Zygosity=Unspecified (PubMed=11559526).
CC   Sequence variation: Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_4Y46 ! MCF-7/AdrVp
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 22-08-17; Last updated: 19-12-24; Version: 12
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RX   PubMed=9178101; DOI=10.1002/(SICI)1097-4644(19970615)65:4<513::AID-JCB7>3.0.CO;2-R;
RA   Lee J.S., Scala S., Matsumoto Y., Dickstein B., Robey R.W., Zhan Z.-R.,
RA   Altenberg G., Bates S.E.;
RT   "Reduced drug accumulation and multidrug resistance in human breast
RT   cancer cells without associated P-glycoprotein or MRP
RT   overexpression.";
RL   J. Cell. Biochem. 65:513-526(1997).
//
RX   PubMed=9892175;
RA   Miyake K., Mickley L.A., Litman T., Zhan Z.-R., Robey R.W.,
RA   Cristensen B., Brangi M.F., Greenberger L.M., Dean M., Fojo A.,
RA   Bates S.E.;
RT   "Molecular cloning of cDNAs which are highly overexpressed in
RT   mitoxantrone-resistant cells: demonstration of homology to ABC
RT   transport genes.";
RL   Cancer Res. 59:8-13(1999).
//
RX   PubMed=11406094; DOI=10.1016/S0005-2736(01)00308-X;
RA   Robey R.W., Honjo Y., van de Laar A., Miyake K., Regis J.T.,
RA   Litman T., Bates S.E.;
RT   "A functional assay for detection of the mitoxantrone resistance
RT   protein, MXR (ABCG2).";
RL   Biochim. Biophys. Acta 1512:171-182(2001).
//
RX   PubMed=11559526;
RA   Honjo Y., Hrycyna C.A., Yan Q.-W., Medina-Perez W.Y., Robey R.W.,
RA   van de Laar A., Litman T., Dean M., Bates S.E.;
RT   "Acquired mutations in the MXR/BCRP/ABCP gene alter substrate
RT   specificity in MXR/BCRP/ABCP-overexpressing cells.";
RL   Cancer Res. 61:6635-6639(2001).
//
RX   PubMed=12116365; DOI=10.1002/cyto.10111;
RA   Minderman H., Suvannasankha A., O'Loughlin K.L., Scheffer G.L.,
RA   Scheper R.J., Robey R.W., Baer M.R.;
RT   "Flow cytometric analysis of breast cancer resistance protein
RT   expression and function.";
RL   Cytometry 48:59-65(2002).
//
RX   PubMed=15901850; DOI=10.1124/mol.105.011015;
RA   Liu Y., Peng H., Zhang J.-T.;
RT   "Expression profiling of ABC transporters in a drug-resistant breast
RT   cancer cell line using AmpArray.";
RL   Mol. Pharmacol. 68:430-438(2005).
//