ID   14.18
AC   CVCL_KR88
SY   ch 14.18
DR   Wikidata; Q54581785
RX   PubMed=2720646;
RX   PubMed=3100030;
CC   Characteristics: Because it binds and kills neuroblastoma cells, was used to develop dinutuximab which is used in a clinical setting.
CC   Monoclonal antibody isotype: IgG3.
CC   Monoclonal antibody target: ChEBI; CHEBI:89637; Ganglioside GD2.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
CA   Hybridoma
DT   Created: 22-08-17; Last updated: 21-03-23; Version: 3
//
RX   PubMed=2720646;
RA   Mujoo K., Kipps T.J., Yang H.-M., Cheresh D.A., Wargalla U.,
RA   Sander D.J., Reisfeld R.A.;
RT   "Functional properties and effect on growth suppression of human
RT   neuroblastoma tumors by isotype switch variants of monoclonal
RT   antiganglioside GD2 antibody 14.18.";
RL   Cancer Res. 49:2857-2861(1989).
//
RX   PubMed=3100030;
RA   Mujoo K., Cheresh D.A., Yang H.-M., Reisfeld R.A.;
RT   "Disialoganglioside GD2 on human neuroblastoma cells: target antigen
RT   for monoclonal antibody-mediated cytolysis and suppression of tumor
RT   growth.";
RL   Cancer Res. 47:1098-1104(1987).
//