ID   14.18
AC   CVCL_KR88
SY   ch 14.18
DR   Wikidata; Q54581785
RX   PubMed=2720646;
RX   PubMed=3100030;
CC   Characteristics: Because it binds and kills neuroblastoma cells, was used to develop dinutuximab which is used in a clinical setting.
CC   Monoclonal antibody isotype: IgG3.
CC   Monoclonal antibody target: ChEBI; CHEBI_89637; Ganglioside GD2.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
CA   Hybridoma
DT   Created: 22-08-17; Last updated: 19-12-24; Version: 4
CH   CVCL_KR89 ! 14.G2a
//
RX   PubMed=2720646;
RA   Mujoo, Kalpana
RA   Kipps, Thomas James
RA   Yang, Hsin-Ming
RA   Cheresh, David A.
RA   Wargalla, Ursula
RA   Sander, Diana J.
RA   Reisfeld, Ralph Alfred
RT   "Functional properties and effect on growth suppression of human
RT   neuroblastoma tumors by isotype switch variants of monoclonal
RT   antiganglioside GD2 antibody 14.18.";
RL   Cancer Res. 49:2857-2861(1989).
//
RX   PubMed=3100030;
RA   Mujoo, Kalpana
RA   Cheresh, David A.
RA   Yang, Hsin-Ming
RA   Reisfeld, Ralph Alfred
RT   "Disialoganglioside GD2 on human neuroblastoma cells: target antigen
RT   for monoclonal antibody-mediated cytolysis and suppression of tumor
RT   growth.";
RL   Cancer Res. 47:1098-1104(1987).
//