ID   Lec13
AC   CVCL_KA69
SY   CHO-Lec13; Pro-Lec13.6a
DR   Wikidata; Q54902419
RX   PubMed=2428310;
RX   PubMed=3456174;
RX   PubMed=11986321;
RX   PubMed=16609957;
CC   Characteristics: Useful for the production of fucose-negative antibodies.
CC   Characteristics: Deficient in GDP-mannose 4,6 dehydratase (GMDS).
CC   Selected for resistance to: UniProtKB; P02867; Pisum sativum lectin.
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_4382 ! CHO Pro-5
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 22-08-17; Last updated: 30-01-24; Version: 7
//
RX   PubMed=2428310; DOI=10.1016/0003-9861(86)90031-7;
RA   Ripka J., Adamany A., Stanley P.;
RT   "Two Chinese hamster ovary glycosylation mutants affected in the
RT   conversion of GDP-mannose to GDP-fucose.";
RL   Arch. Biochem. Biophys. 249:533-545(1986).
//
RX   PubMed=3456174; DOI=10.1007/BF01560727;
RA   Ripka J., Stanley P.;
RT   "Lectin-resistant CHO cells: selection of four new pea
RT   lectin-resistant phenotypes.";
RL   Somat. Cell Mol. Genet. 12:51-62(1986).
//
RX   PubMed=11986321; DOI=10.1074/jbc.M202069200;
RA   Shields R.L., Lai J., Keck R., O'Connell L.Y., Hong K., Meng Y.G.,
RA   Weikert S.H.A., Presta L.G.;
RT   "Lack of fucose on human IgG1 N-linked oligosaccharide improves
RT   binding to human Fcgamma RIII and antibody-dependent cellular
RT   toxicity.";
RL   J. Biol. Chem. 277:26733-26740(2002).
//
RX   PubMed=16609957; DOI=10.1002/bit.20880;
RA   Kanda Y., Yamane-Ohnuki N., Sakai N., Yamano K., Nakano R.,
RA   Inoue-Urakubo M., Misaka H., Iida S., Wakitani M., Konno Y., Yano K.,
RA   Shitara K., Hosoi S., Satoh M.;
RT   "Comparison of cell lines for stable production of fucose-negative
RT   antibodies with enhanced ADCC.";
RL   Biotechnol. Bioeng. 94:680-688(2006).
//