ID   184
AC   CVCL_K049
SY   HMEC-184; HMEC 184; HMEC184
DR   EFO; EFO_0001190
DR   Wikidata; Q54582473
RX   PubMed=8504475;
RX   PubMed=9398663;
RX   PubMed=9671407;
RX   PubMed=10739701;
CC   Senescence: Senesces at ~80 PDL (PubMed=9398663).
CC   Doubling time: 2.5 days (PubMed=9671407).
CC   Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008359.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   21Y
CA   Finite cell line
DT   Created: 11-02-13; Last updated: 05-10-23; Version: 12
RX   PubMed=8504475; DOI=10.1093/carcin/14.5.833;
RA   Lehman T.A., Modali R., Boukamp P., Stanek J., Bennett W.P.,
RA   Welsh J.A., Metcalf R.A., Stampfer M.R., Fusenig N.E., Rogan E.M.,
RA   Harris C.C.;
RT   "p53 mutations in human immortalized epithelial cell lines.";
RL   Carcinogenesis 14:833-839(1993).
RX   PubMed=9398663; DOI=10.1091/mbc.8.12.2391;
RA   Stampfer M.R., Bodnar A.G., Garbe J.C., Wong M., Pan A.,
RA   Villeponteau B., Yaswen P.;
RT   "Gradual phenotypic conversion associated with immortalization of
RT   cultured human mammary epithelial cells.";
RL   Mol. Biol. Cell 8:2391-2405(1997).
RX   PubMed=9671407; DOI=10.1038/sj.onc.1201814;
RA   Sweeney K.J., Swarbrick A., Sutherland R.L., Musgrove E.A.;
RT   "Lack of relationship between CDK activity and G1 cyclin expression in
RT   breast cancer cells.";
RL   Oncogene 16:2865-2878(1998).
RX   PubMed=10739701; DOI=10.1006/gyno.2000.5734;
RA   Annab L.A., Terry L., Cable P.L., Brady J., Stampfer M.R.,
RA   Barrett J.C., Afshari C.A.;
RT   "Establishment and characterization of a breast cell strain containing
RT   a BRCA1 185delAG mutation.";
RL   Gynecol. Oncol. 77:121-128(2000).