ID   184
AC   CVCL_K049
SY   HMEC-184; HMEC 184; HMEC184
DR   EFO; EFO_0001190
DR   GEO; GSM200748
DR   GEO; GSM200749
DR   GEO; GSM200754
DR   GEO; GSM200755
DR   GEO; GSM200756
DR   GEO; GSM200757
DR   Wikidata; Q54582473
RX   PubMed=8504475;
RX   PubMed=9398663;
RX   PubMed=9671407;
RX   PubMed=10739701;
RX   PubMed=16849555;
WW   Info; -; -; https://hmec.lbl.gov/mreview.htm
CC   Senescence: Senesces at ~80 PDL (PubMed=9398663).
CC   Doubling time: 2.5 days (PubMed=9671407).
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008367.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   21Y
CA   Finite cell line
DT   Created: 11-02-13; Last updated: 10-04-25; Version: 14
CH   CVCL_K053 ! 184-hTERT
CH   CVCL_3040 ! 184A1
CH   CVCL_4688 ! 184B5
CH   CVCL_B0AX ! 184E6E7
//
RX   PubMed=9398663; DOI=10.1091/mbc.8.12.2391; PMCID=PMC25715;
RA   Stampfer, Martha Ruskin
RA   Bodnar, Andrea G.
RA   Garbe, James C.
RA   Wong, Michelle
RA   Pan, Alison
RA   Villeponteau, Bryant
RA   Yaswen, Paul
RT   "Gradual phenotypic conversion associated with immortalization of
RT   cultured human mammary epithelial cells.";
RL   Mol. Biol. Cell 8:2391-2405(1997).
//
RX   PubMed=9671407; DOI=10.1038/sj.onc.1201814;
RA   Sweeney, Kimberley J.
RA   Swarbrick, Alexander
RA   Sutherland, Robert Lyndsay
RA   Musgrove, Elizabeth A.
RT   "Lack of relationship between CDK activity and G1 cyclin expression in
RT   breast cancer cells.";
RL   Oncogene 16:2865-2878(1998).
//
RX   PubMed=16849555; DOI=10.1158/0008-5472.CAN-06-0515; PMCID=PMC2933218;
RA   Fournier, Marcia Vasconcelos
RA   Martin, Katherine J.
RA   Kenny, Paraic A.
RA   Xhaja, Kris
RA   Bosch, Irene
RA   Yaswen, Paul
RA   Bissell, Mina J.
RT   "Gene expression signature in organized and growth-arrested mammary
RT   acini predicts good outcome in breast cancer.";
RL   Cancer Res. 66:7095-7102(2006).
//
RX   PubMed=8504475; DOI=10.1093/carcin/14.5.833;
RA   Lehman, Teresa A.
RA   Modali, Ramakrishna V.
RA   Boukamp, Petra
RA   Stanek, Julie
RA   Bennett, William P.
RA   Welsh, Judith A.
RA   Metcalf, Robert A.
RA   Stampfer, Martha Ruskin
RA   Fusenig, Norbert E.
RA   Rogan, Eileen M.
RA   Harris, Curtis Craig
RT   "p53 mutations in human immortalized epithelial cell lines.";
RL   Carcinogenesis 14:833-839(1993).
//
RX   PubMed=10739701; DOI=10.1006/gyno.2000.5734;
RA   Annab, Lois Anderson
RA   Terry, Lori
RA   Cable, P. LouAnn
RA   Brady, Jennifer
RA   Stampfer, Martha Ruskin
RA   Barrett, J. Carl
RA   Afshari, Cynthia A.
RT   "Establishment and characterization of a breast cell strain containing
RT   a BRCA1 185delAG mutation.";
RL   Gynecol. Oncol. 77:121-128(2000).
//