ID   Kasumi-1 R48
AC   CVCL_JY44
SY   R48
DR   cancercelllines; CVCL_JY44
DR   GEO; GSM955192
DR   GEO; GSM955193
DR   GEO; GSM955194
DR   Wikidata; Q54899514
RX   PubMed=24211243;
CC   Population: Japanese.
CC   Selected for resistance to: ChEBI; CHEBI:49375; Dasatinib (BMS-354825).
CC   Sequence variation: Gene fusion; HGNC; 10471; RUNX1 + HGNC; 1535; RUNX1T1; Name(s)=RUNX1-RUNX1T1, AML1-ETO (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6342; KIT; Simple; p.Asn822Lys (c.2466T>A) (N818K); ClinVar=VCV000375931; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9811; RAD21; Simple; p.Lys330Profs*6 (c.987insCCGG); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9381; Childhood acute myeloid leukemia with maturation
DI   ORDO; Orphanet_98834; Acute myeloblastic leukemia with maturation
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0589 ! Kasumi-1
SX   Male
AG   7Y
CA   Cancer cell line
DT   Created: 22-08-17; Last updated: 05-10-23; Version: 13
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RX   PubMed=24211243; DOI=10.1016/j.exphem.2013.10.006;
RA   Herrmann M.D., Lennerz J.K., Bullinger L., Bartholomae S.,
RA   Holzmann K., Westhoff M.-A., Corbacioglu S., Debatin K.-M.;
RT   "Transitory dasatinib-resistant states in KIT(mut) t(8;21) acute
RT   myeloid leukemia cells correlate with altered KIT expression.";
RL   Exp. Hematol. 42:90-100(2014).
//