ID   NCI-hTERT-CL6
AC   CVCL_JY26
DR   cancercelllines; CVCL_JY26
DR   Wikidata; Q54908204
RX   PubMed=26074691;
CC   Characteristics: Overexpresses TERT; compared to the parent cell line, it has better adhesion properties, ability to be maintained in culture for longer periods after confluency and is more efficient in mucins MUC1, MUC2 and MUC13 secretion (PubMed=26074691).
CC   Sequence variation: Gene deletion; HGNC; HGNC:6770; SMAD4; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3431; ERBB3; Simple; p.Thr757Lys (c.2270C>A); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
DI   NCIt; C5473; Gastric tubular adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1603 ! NCI-N87
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 22-08-17; Last updated: 19-12-24; Version: 16
//
RX   PubMed=26074691; DOI=10.3748/wjg.v21.i21.6526; PMCID=PMC4458763;
RA   Saraiva-Pava, Kathy
RA   Navabi, Nazanin
RA   Skoog, Emma C.
RA   Linden, Sara K.
RA   Oleastro, Monica
RA   Roxo-Rosa, Monica
RT   "New NCI-N87-derived human gastric epithelial line after human
RT   telomerase catalytic subunit over-expression.";
RL   World J. Gastroenterol. 21:6526-6542(2015).
//