ID   NCI-hTERT-CL5
AC   CVCL_JY25
DR   cancercelllines; CVCL_JY25
DR   Wikidata; Q54908203
RX   PubMed=26074691;
CC   Characteristics: Overexpresses TERT; compared to the parent cell line, it has better adhesion properties, ability to be maintained in culture for longer periods after confluency and is more efficient in mucins MUC1, MUC2 and MUC13 secretion (PubMed=26074691).
CC   Sequence variation: Gene deletion; HGNC; 6770; SMAD4; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3431; ERBB3; Simple; p.Thr757Lys (c.2270C>A); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
CC   Transfected with: HGNC; 11730; TERT.
CC   Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
DI   NCIt; C5473; Gastric tubular adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1603 ! NCI-N87
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 22-08-17; Last updated: 05-10-23; Version: 14
//
RX   PubMed=26074691; DOI=10.3748/wjg.v21.i21.6526;
RA   Saraiva-Pava K., Navabi N., Skoog E.C., Linden S.K., Oleastro M.,
RA   Roxo-Rosa M.;
RT   "New NCI-N87-derived human gastric epithelial line after human
RT   telomerase catalytic subunit over-expression.";
RL   World J. Gastroenterol. 21:6526-6542(2015).
//