ID   LdlF
AC   CVCL_JY00
SY   ldlF; CHO ldlF
DR   Wikidata; Q54902385
RX   PubMed=8063714;
RX   PubMed=8207054;
RX   PubMed=8626666;
CC   Characteristics: At the non-permissive temperature of 39.5 Celsius exhibits rapid degradation of LDLRs, disruption of ER-through Golgi transport and disintegration of the Golgi apparatus.
CC   Sequence variation: Mutation; UniProtKB; Q60445; Cope; Simple; p.Glu251Lys (c.751C>T); Zygosity=Homozygous (PubMed=8626666).
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_0214 ! CHO-K1
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 22-08-17; Last updated: 30-01-24; Version: 12
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RX   PubMed=8063714; DOI=10.1016/S0021-9258(17)31915-4;
RA   Hobbie L., Fisher A.S., Lee S., Flint A., Krieger M.;
RT   "Isolation of three classes of conditional lethal Chinese hamster
RT   ovary cell mutants with temperature-dependent defects in low density
RT   lipoprotein receptor stability and intracellular membrane transport.";
RL   J. Biol. Chem. 269:20958-20970(1994).
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RX   PubMed=8207054; DOI=10.1083/jcb.125.6.1213;
RA   Guo Q., Vasile E., Krieger M.;
RT   "Disruptions in Golgi structure and membrane traffic in a conditional
RT   lethal mammalian cell mutant are corrected by epsilon-COP.";
RL   J. Cell Biol. 125:1213-1224(1994).
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RX   PubMed=8626666; DOI=10.1074/jbc.271.19.11191;
RA   Guo Q., Penman M., Trigatti B.L., Krieger M.;
RT   "A single point mutation in epsilon-COP results in
RT   temperature-sensitive, lethal defects in membrane transport in a
RT   Chinese hamster ovary cell mutant.";
RL   J. Biol. Chem. 271:11191-11196(1996).
//