ID   DKFZ-BT66
AC   CVCL_JX58
DR   Wikidata; Q54831117
RX   PubMed=28002790;
RX   PubMed=35977048;
CC   Characteristics: Transduced with a doxycycline-inducible system coding for SV40 large T antigen and RFP (PubMed=28002790).
CC   Senescence: Withdrawal of doxycyclin leads to senescence (PubMed=28002790).
CC   Doubling time: 45 hours (PubMed=28002790).
CC   Sequence variation: Gene fusion; HGNC; HGNC:1097; BRAF + HGNC; HGNC:22219; KIAA1549; Name(s)=KIAA1549-BRAF; Note=KIAA1549 exon 16 fused to BRAF exon 9 (PubMed=28002790).
CC   Genetic integration: Method=Transduction; Gene=FPbase; EGE3L; DsRed (Note=drFP583, red fluorescent protein from Discosoma sp.).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Brain, cerebellum; UBERON=UBERON_0002037.
DI   NCIt; C4047; Pilocytic astrocytoma
DI   ORDO; Orphanet_251612; Pilocytic astrocytoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   2Y
CA   Cancer cell line
DT   Created: 22-08-17; Last updated: 19-12-24; Version: 10
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RX   PubMed=28002790; DOI=10.18632/oncotarget.14004; PMCID=PMC5355278;
RA   Selt F., Hohloch J., Hielscher T., Sahm F., Capper D., Korshunov A.,
RA   Usta D., Brabetz S., Ridinger J., Ecker J., Oehme I., Gronych J.,
RA   Marquardt V., Pauck D., Bachli H., Stiles C.D., von Deimling A.,
RA   Remke M., Schuhmann M.U., Pfister S.M., Brummer T., Jones D.T.W.,
RA   Witt O., Milde T.;
RT   "Establishment and application of a novel patient-derived
RT   KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for
RT   preclinical drug testing.";
RL   Oncotarget 8:11460-11479(2017).
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RX   PubMed=35977048; DOI=10.1093/neuonc/noac199; PMCID=PMC10076946;
RA   Selt F., Sigaud R., Valinciute G., Sievers P., Zaman J., Alco C.,
RA   Schmid S., Peterziel H., Tsai J.W., Guiho R., Martinez-Barbera J.P.,
RA   Pusch S., Deng J., Zhai Y.-F., van Tilburg C.M., Schuhmann M.U.,
RA   El Damaty A., Bandopadhayay P., Herold-Mende C., von Deimling A.,
RA   Pfister S.M., Montero J., Capper D., Oehme I., Sahm F., Jones D.T.W.,
RA   Witt O., Milde T.;
RT   "BH3 mimetics targeting BCL-XL impact the senescent compartment of
RT   pilocytic astrocytoma.";
RL   Neuro-oncol. 25:735-747(2023).
//