ID   BEL-A
AC   CVCL_JM04
SY   BEL-A2; Bristol Erythroid Line-Adult
DR   Wikidata; Q54795987
RX   CelloPub=CLPUB00710;
RX   PubMed=28290447;
RX   PubMed=31753923;
WW   http://www.sciencealert.com/immortal-stem-cells-let-scientists-create-an-unlimited-supply-of-artificial-blood
CC   Characteristics: Differentiates efficiently into mature, functional reticulocytes.
CC   Doubling time: 20 hours (PubMed=28290447); 18.7 +- 2.0 hours (PubMed=31753923).
CC   Transfected with: UniProtKB; P03126; Human papillomavirus type 16 protein E6.
CC   Transfected with: UniProtKB; P03129; Human papillomavirus type 16 protein E7.
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
CC   Cell type: Mononuclear cell; CL=CL_0000842.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Adult
CA   Transformed cell line
DT   Created: 15-05-17; Last updated: 05-10-23; Version: 12
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RX   CelloPub=CLPUB00710;
RA   Hawksworth J.S.;
RT   "CRISPR-Cas9 gene editing in an immortalized erythroid cell line for
RT   production of engineered red blood cells.";
RL   Thesis PhD (2019), University of Bristol, United Kingdom.
//
RX   PubMed=28290447; DOI=10.1038/ncomms14750;
RA   Trakarnsanga K., Griffiths R.E., Wilson M.C., Blair A.,
RA   Satchwell T.J., Meinders M., Cogan N., Kupzig S., Kurita R.,
RA   Nakamura Y., Toye A.M., Anstee D.J., Frayne J.;
RT   "An immortalized adult human erythroid line facilitates sustainable
RT   and scalable generation of functional red cells.";
RL   Nat. Commun. 8:14750.1-14750.7(2017).
//
RX   PubMed=31753923; DOI=10.3324/haematol.2019.229211;
RA   Daniels D.E., Downes D.J., Ferrer-Vicens I., Ferguson D.C.J.,
RA   Singleton B.K., Wilson M.C., Trakarnsanga K., Kurita R., Nakamura Y.,
RA   Anstee D.J., Frayne J.;
RT   "Comparing the two leading erythroid lines BEL-A and HUDEP-2.";
RL   Haematologica 105:E389-E394(2020).
//